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Ming-Hong Tai / Professor

戴明泓

專長領域:基因傳送/治療、癌症科學/血管新生、神經科學/再生、基因工程

聯絡電話:07-5252000分機:5816

E-mail:minghongtai@gmail.com

學歷
1984 成功大學化學系學士
1989 台灣大學生化學研究所碩士
1993 美國Baylor College of Medicine生物化學博士
經歷
1994 - 1996 The Scripps Research Institute博士後研究員
1997 - 2008 中山大學生物科學研究所兼任副教授
1996 - 2006 高雄榮民總醫院副研究員
2006 - 2008 高雄榮民總醫院研究員
2008 - 2010 國立中山大學生物醫學研究所副教授
  1997 - 高雄醫學大學生物化學研究所兼任副教授
2010- 國立中山大學生物醫學研究所教授
研究領域
1.基因傳送/治療
2.癌症科學/血管新生
3.神經科學/再生
  4.基因工程
學術榮譽
國科會甲種研究獎勵
學術著作
出版年月 著作類別 著作名稱 作者 收錄出處
2018-12 期刊論文 Delta-like 1 homologue promotes tumorigenesis and epithelial-mesenchymal transition of ovarian high-grade serous carcinoma through activation of Notch signaling. Huang CC, Cheng SH, Wu CH, Li WY, Wang JS, Kung ML, Chu TH, Huang ST, Feng CT, Hung SC, Tai MH. Oncogene
2018-12 期刊論文 Helicobacter pylori Infection-Induced Hepatoma-Derived Growth Factor Regulates the Differentiation of Human Mesenchymal Stem Cells to Myofibroblast-Like Cells. Liu CJ, Wang YK, Kuo FC, Hsu WH, Yu FJ, Hsieh S, Tai MH, Wu DC, Kuo CH. Cancers (Basel)
2018-12 期刊論文 α-Melanocyte-Stimulating Hormone Attenuates Neovascularization by Inducing Nitric Oxide Deficiency via MC-Rs/PKA/NF-κB Signaling. Weng WT, Wu CS, Wang FS, Wu CY, Ma YL, Chan HH, Wu DC, Wu JC, Chu TH, Huang SC, Tai MH. Int J Mol Sci.
2018-09 期刊論文 Inhibition of Experimental Choroidal Neovascularization by a Novel Peptide Derived from Calreticulin Anti-Angiogenic Domain. Bee YS, Ma YL, Chen Jinying, Tsai PJ ,Sheu SJ, Lin HC, Huang H, Liu GS , and Tai MH Int J Mol Sci.
2018-08 期刊論文 BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 Signaling. Chung YH, Huang YH, Chu TH, Chen CL, Lin PR, Huang SC, Wu DC, Huang CC, Hu TH, Kao YH, Tai MH Laboratory Investigation
2018-07 期刊論文 Autophagic Cell Death Participates in POMC-induced Melanoma Suppression. Cell Death and Discovery. Wu JC, Tsai HE, Liu GS, Wu CS, Tai MH Cell Death Discov.
2018-04 期刊論文 Celecoxib enhances the therapeutic efficacy of epirubicin for Novikoff hepatoma in rats Chu TH, Chan HH, Hu TH, Wang EM, Ma YL, Huang SC, Wu JC, Chang YC, Weng WT, Wen ZH, Wu DC, Chen YA, Tai MH Cancer Medicine
2018-03 期刊論文 Soluble delta-like 1 homolog (DLK1) stimulates angiogenesis through Notch1/Akt/eNOS signaling in endothelial cells Huang CC, Kuo HM, Wu PC, Cheng SH, Chang TT, Chang YC, Kung ML, Wu DC, Chuang JH, Tai MH. Angiogenesis
2018-01 期刊論文 Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor Li-Ying Chen, Yen-Chieh Huang, Shih-Tsung Huang, Yin-Cheng Hsieh, Hong-Hsiang Guan, Nai-Chi Chen, Phimonphan Chuankhayan, Masato Yoshimura, Ming-Hong Tai, and Chun-Jung Chen Sci Rep
2017-08 期刊論文 MiR-30a-5p Inhibits Epithelial-to-Mesenchymal Transition and Upregulates. Expression of Tight Junction Protein Claudin-5 in Human Upper Tract Urothelial Carcinoma Cells. Chung YH, Li SC, Kao YH, Luo HL, Cheng YT, Lin PR, Tai MH, Chiang PH Int J Mol Sci.
2017-03 期刊論文 Gene delivery of calreticulin anti-angiogenic domain attenuates the development of choroidal neovascularization in rats. Bee YS, Tu L, Sheu SJ, Lin HC, Tang JH, Wang JH, Prea SM, Dusting GJ, Wu DC, Zhong J, Bui BV, Tai MH, Liu GS. Hum Gene Ther.
2017-02 期刊論文 Prdx1-encoded peroxiredoxin is important for vascular development in zebrafish Huang PC, Chiu CC, Chang HW, Wang YS, Syue HH, Song YC, Weng ZH, Tai MH, Wu CY. FEBS Lett.
2017-01 期刊論文 Ftr82 Is Critical for Vascular Patterning during Zebrafish Development Chang HW, Wang WD, Chiu CC, Chen CH, Wang YS, Chen ZY, Liu W, Tai MH, Wen ZH, Wu CY. Int J Mol Sci.
2016-12 期刊論文 Heteronemin Is a Novel c-Met/STAT3 Inhibitor Against Advanced Prostate Cancer Cells. Wu JC, Wang CT, Hung HC, Wu WJ, Wu DC, Chang MC, Sung PJ, Chou YW, Wen ZH,Tai MH* Prostate.
2016-09 期刊論文 Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation. Hung AC, Lo S, Hou MF, Lee YC, Tsai CH, Chen YY, Liu W, Su YH, Lo YH, Wang CH, Wu SC, Hsieh YC, Hu SC, Tai MH, Wang YM, Yuan SF. Clin Cancer Res.
2016-04 期刊論文 Altered mitochondrial dynamics and response to insulin in cybrid cells harboring a diabetes-susceptible mitochondrial DNA haplogroup. Kuo HM, Weng SW, Chang AY, Huang HT, Lin HY, Chuang JH, Lin TK, Liou CW, Tai MH, Lin CY, Wang PW. Free Radic Biol Med.
2016-03 期刊論文 Nanoscale characterization illustrates the cisplatin-mediated biomechanical changes of B16-F10 melanoma cells. Kung ML, Hsieh CW, Tai MH, Weng CH, Wu DC, Wu WJ, Yeh BW, Hsieh SL,Kuo CH, Hung HS, Hsieh S. Phys Chem Chem Phys.
2016-01 期刊論文 The role of the PI3K/Akt/mTOR pathway in glial scar formation following spinal cord injury. Chen CH, Sung CS, Huang SY, Feng CW, Hung HC, Yang SN, Chen NF, Tai MH, Wen ZH, Chen WF. Exp Neurol.
2015-12 期刊論文 Gene Delivery by Subconjunctival Injection of Adenovirus in Rats: A Study of Local Distribution, Transgene Duration and Safety Liu GS, Wang JH, Lee JH, Tsai PJ, Tsai HE, Sheu SJ, Lin HC, Dusting GJ, Tai MH, Bee YS. PLoS One
2015-06 期刊論文 Differential Recruitment of Dentate Gyrus Interneuron Types by Commissural Versus Perforant Pathways Hsu TT, Lee CT, Tai MH, Lien CC Cerebral Cortex
2015-06 期刊論文 Hepatoma-derived Growth Factor/Nucleolin Axis as a Novel Oncogenic Pathway in Liver Carcinogenesis Chen S.-C., Hu, T.-H., Chan, H.-H., Li-Fen Liu, Mei-Lang Kung, Shih-Wei Lin, E-Ming Wang, Wu, H-C., Chang, M.-C.*, Tai, M.-H.* Oncotarget
2015-03 期刊論文 Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain Huang SY, Sung CS, Chen WF, Chen CH, Feng CW, Yang SN, Hung HC, ChenNF, Lin PR, Chen SC, Wang HM, Chu TH, Tai, M.-H.*, Wen ZH* Journal of Neuroinflammation
2015-02 期刊論文 Coral-Derived Compound WA-25 Inhibits Angiogenesis by Attenuating the VEGF/VEGFR2 Signaling Pathway Lin SW, Huang SC, Kuo HM, Chen CH, Ma YL, Chu TH, Bee YS, Wang EM, Wu CY, Sung PJ, Wen ZH, Wu DC, Sheu JH, Tai, M.-H.* Marine Drugs
2014-11 期刊論文 Hepatoma-derived growth factor upregulation is correlated with prognostic factors of early-stage cervical adenocarcinoma Tsai CC, Huang SC, Tai MH, Chien CC, Huang CC, Hsu YC. Int J Mol Sci.
2014-09 期刊論文 A novel poly-naphthol compound ST104P suppresses angiogenesis by attenuating matrix metalloproteinase-2 expression in endothelial cells. Ma YL, Lin SW, Fang HC, Chou KJ, Bee YS, ChuTH, Chang MC, Weng WT, Wu CY, Cho CL, Tai, M.-H. Int J Mol Sci.
2014-05 期刊論文 Functional Production of a Soluble and Secreted Single- Chain Antibody by a Bacterial Secretion System Cheng CM, Tzou SC, Zhuang YH, Huang CC, Kao CH, Liao KW, Cheng TC4 Chuang CH, Hsieh YC, Tai, M.-H., Cheng TL. PLoS One
2014-05 期刊論文 Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation Liu GS, Wu JC, Tsai HE, Dusting GJ, Chan EC, Wu CS, Tai, M.-H. Free Radic Biol Med.
2014-03 期刊論文 Adenoviral-mediated glial cell line-derived neurotrophic factor gene transfer has a protective effect on sciatic nerve following constriction-induced spinal cord injury Chou AK, Yang MC, Tsai HP, Chai CY, Tai, M.-H., Kwan AL, Hong YR. PLoS One
2014-03 期刊論文 Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Tian-Huei Chu,Hoi-Hung Chan, Hsiao-Mei Kuo, Li-Fen Liu, Tsung-Hui Hu, Cheuk-Kwan Sun, Mei-Lang Kung, Shih-Wei Lin, E-Ming Wang, Yi-Ling Ma, Kwan-Hung Cheng, Kwok Hung Lai, Zhi-Hong Wen, Ping-I Hsu and Ming-Hong Tai Oncotarget
2014-03 期刊論文 Dexamethasone downregulated the expression of CSF 14-3-3 protein in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection Tsai HC, Lee BY, Yen CM, Wann SR, Lee SSJ, Chen YS, Tai, M.-H. Acta Trop
2014-02 期刊論文 14-3-3β protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection Tsai HC, Huang YL, Chen YS, Yen CM, Tsai R, Lee SS, Tai, M.-H. BMC Res Notes.
2014-01 期刊論文 Biphasic Response of Mitochondrial Biogenesis to Oxidative Stress in Visceral Fat of Diet-Induced Obesity Mice Wang PW, Kuo HM, Huang HT, Chang AY, Weng SW, Tai, M.-H., Chuang JH, Chen IY, Huang SC, Lin TK, Liou CW Antioxid Redox Signal.
2014-01 期刊論文 α-Melanocyte-stimulating hormone inhibits angiogenesis through attenuation of VEGF/VEGFR2 signaling pathway Weng WT, Huang SC, Ma YL, Chan HH, Lin SW, Wu JC, Wu CY, Wen ZH, Wang EM, Wu CL, Tai, M.-H. Biochim Biophys Acta.
2013-03 期刊論文 Downregulation of Hepatoma-derived Growth Factor Contributes to Retarded Lung Metastasis via inhibition of Epithelial-Mesenchymal Transition by Systemic POMC Gene Delivery in Melanoma Tsai HE, Liu GS, Kung ML, Liu LF, Wu JC, Tang CH, Huang CH, Chen SC, Lam HC, Wu CS, Tai, M.-H. Mol Cancer Ther.
2013-03 期刊論文 Toll-like receptor 3 expression inhibits cell invasion and migration and predicts a favorable prognosis in neuroblastoma Hsu WM, Huang CC, Wu PY, Lee H, Huang MC, Tai, M.-H., Chuang JH. Cancer Lett.
2013-03 期刊論文 Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma Tsai HE, Wu JC, Kung ML, Liu LF, Kuo LH, Kuo HM, Chen SC, Chan EC, Wu CS, Tai, M.-H.*, Liu, G.-S.* PLoS One.
2013-02 期刊論文 2-Deoxyglucose treatment complements the cisplatin- or BH3-only mimetic-induced suppression of neuroblastoma cell growth. Chuang JH, Chou MH, Tai, M.-H., Lin TK, Liou CW, Chen T, Hsu WM, Wang PW. Int J Biochem Cell Biol.
2012-08 期刊論文 Hepatoma-derived Growth Factor Stimulates Podosome Rosettes Formation in NIH/3T3 Cells through the Activation of Phosphatidylinositol 3-kinase/Akt Pathway. Kung ML, Tsai HE, Hu TH, Kuo HM, Liu LF, Chen SC, Lin PR, Ma YL, Wang EM, Liu GS, Liu JK, Tai MH. Biochem. Biophys. Res. Commun.
2012-05 期刊論文 Hepatoma-Derived Growth Factor Regulates breast cancer cell invasion by Modulating Epithelial Mesenchymal Transition. Chen SC, Kung ML, Hu TH, Chen HY, Wu JC, Kuo HM, Tsai HE, Lin YW, Wen ZH, Liu JK, Yeh MH, Tai MH. JOURNAL OF PATHOLOGY
2012-04 期刊論文 Preferential involvement of mitochondria in Toll-like receptor 3 agonist-induced neuroblastoma cell apoptosis, but not in inhibition of cell growth. Chuang JH, Lin TK, Tai MH, Liou CW, Huang ST, Wu CL, Lin HY, Wang PW. Apoptosis
2012-04 期刊論文 Ultraviolet C Irradiation Induces Different Expression of Cyclooxygenase 2 in NIH 3T3 Cells and A431 Cells: The Roles of COX-2 Are Different in Various Cell Lines. Tai MH, Weng CH, Mon DP, Hu CY, Wu MH. Int J Mol Sci.
2012-03 期刊論文 Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas. Hsu SS, Chen CH, Liu GS, Tai MH, Wang JS, Wu JC, Kung ML, Chan EC, Liu LF. J Neurooncol.
2012-02 期刊論文 The expression and prognostic significance of hepatoma-derived growth factor in oral cancer. Lin YW, Li CF, Chen HY, Yen CY, Lin LC, Huang CC, Huang HY, Wu PC, Chen CH, Chen SC, Tai MH. ORAL ONCOLOGY
2012-01 期刊論文 Pro-opiomelanocortin gene delivery suppresses the growth of established Lewis lung carcinoma through a melanocortin-1 receptor-independent pathway. Tsai HE, Liu LF, Dusting GJ, Weng WT, Chen SC, Kung ML, Tee R, Liu GS, Tai MH J Gene Med.
2011-08 期刊論文 Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells. Chuang JH, Chuang HC, Huang CC, Wu CL, Du YY, Kung ML, Chen CH, Chen SC, Tai MH. J Biomed Sci.
2011-08 期刊論文 Heat shock protein 60 protects skeletal tissue against glucocorticoid-induced bone mass loss by regulating osteoblast survival. Wang FS, Wu RW, Ko JY, Tai MH, Ke HC, Yeh DW, Wu SL, Chen MW. Bone
2011-06 期刊論文 Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Exerts Protective Effect on Axons in Sciatic Nerve Following Constriction-Induced Peripheral Nerve Injury. Shi, J.-Y. Liu, G.-S., Huang, H.-T., Liu, L.-F., Kuo, H.-M., Ton, C.-H., Wen, Z.-H., Tee, R., Chen, C.-H., Chao, D., Tai, M.-H. HUMAN GENE THERAPY
2011-06 期刊論文 Mechanisms underlying Benzyl Alcohol Cytotoxicity (Triamcinolone Acetonide Preservative) in Human Retinal Pigment Epithelial Cells. Chang YS, Lin CF, Wu CL, Kuo PY, Wu FS, Shieh CC, Gean PW, Chen ST, Chen MS, Wu WC, Tai, M.-H., Tseng SH. Invest Ophthalmol Vis Sci
2011-05 期刊論文 Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with HIV-1 infection and syphilis or neurosyphilis. HC, Ye SY, Kunin CM, Lee SS, Wann SR, Tai, M.-H., Shi MH, Liu YC, Chen YS. Cytokine
2011-03 期刊論文 Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis. Shen PC, Shiau AL, Jou IM, Lee CH, Tai, M.-H., Juan HY, Lin PR, Liu GS, Wu CL, Hsieh JL. Exp Biol Med (Maywood)
2011-02 期刊論文 Systemic Pro-opiomelanocortin Expression Induces Melanogenic Differentiation and Inhibits Tumor Angiogenesis in Established Mouse Melanoma. Liu GS et al. HUMAN GENE THERAPY
2010-07 期刊論文 Rapid induction of orthotopic hepatocellular carcinoma in immune-competent rats by non-invasive ultrasound-guided cells implantation. Chan HH et al. BMC Gastroenterol.
2010-05 期刊論文 Development of a universal anti-polyethylene glycol reporter gene for noninvasive imaging of PEGylated probes. Chuang KH et al. J Nucl Med
2010-04 期刊論文 Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor. Huang YF et al. J Neurosci
2010-04 期刊論文 Topical application of recombinant calreticulin peptide, vasostatin 48, alleviates laser-induced choroidal neovascularization in rats. 15. Bee YS et al. Molecular Vision
2010-02 期刊論文 Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesi Ying-Hsien Kao JOURNAL OF HEPATOLOGY

 

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