張榮賢 特聘教授
專長領域：白血病研究、白血病幹細胞、致癌及癌症治療細胞訊息傳導路徑、基因甲基化、基因表觀調控、藥物基因體學、蛋白質藥物、小分子藥物、核酸適體、轉譯奈米醫學
聯絡電話：07-5252000分機:7103、7110
E-mail:lschang@mail.nsysu.edu.tw
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| 1981 | 高雄醫學院藥學士 | |
| 1983 | 清華大學分子生物研究所碩士 | |
| 1989 | 清華大學生命科學研究所博士 | |
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| 1989-1991 | 清華大學生命科學研究所博士後研究 | |
| 1991-1992 | 康乃爾大學生化科副研究員 | |
| 1992-1998 | 高雄醫學院生化科副教授 | |
| 1998-1999 | 高雄醫學院生化科教授 | |
| 1999- | 中山大學生物醫學所教授 | |
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| 1.抑癌轉譯醫學及訊息傳導 | ||
| 2.生技醫藥研發 | ||
| 3.蛋白質折疊與致病機轉 | ||
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| 83年至88年國科會甲種研究獎助 | ||
| 86年至89年績優新進研究人員專案計畫 | ||
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| 出版年月 | 著作類別 | 著作名稱 | 作者 | 收錄出處 |
|---|---|---|---|---|
| 2020-12 | 期刊論文 | Blocking of negative charged carboxyl groups converts Naja atra neurotoxin to cardiotoxin-like protein | Shi, Y.J., Chiou, J.T., Wang, L.J., Huang, C.H., Lee, Y.C., Chen, Y.J., Chang, L.S. | International Journal of Biological. Macromolecules |
| 2020-11 | 期刊論文 | Blocking of negative charged carboxyl groups converts Naja atra neurotoxin to cardiotoxin-like protein | Shi, Y.J., Chiou, J.T., Huang, C.H., Lee, Y.C., Wang, L.J., Chang, L.S. | International Journal of Biological. Macromolecules |
| 2020-08 | 期刊論文 | Compound C induces autophagy and apoptosis in parental and hydroquinone-selected malignant leukemia cells through the ROS/p38 MAPK/AMPK/TET2/FOXP3 axis. | Chiou, J.T., Huang, C.H., Lee, Y.C., Wang, L.J., Shi, Y.J., Chen, Y.J., Chang, L.S. | Cell biology and Toxicology |
| 2020-08 | 期刊論文 | Inhibition of EGFR pathway promotes the cytotoxicity of ABT-263 in human leukemia K562 cells by blocking MCL1 upregulation | Lee, Y.C., Wang, L.J., Huang, C.H., Chiou, J.T., Shi, Y.J., Chang, L.S. | Biochemical Pharmacology |
| 2020-05 | 期刊論文 | Inhibition of EGFR pathway promotes the cytotoxicity of ABT-263 in human leukemia K562 cells by blocking MCL1 upregulation | Wang, L.J., Liou, L.R., Shi, Y.J., Chiou, J.T., Lee, Y.C., Hung, C.H., Huang, P.W., Chang, L.S. | International Journal of Molecular Sciences |
| 2020-04 | 期刊論文 | Arsenic trioxide-induced p38 MAPK- and Akt-mediated MCL1 downregulation causes apoptosis of BCR-ABL1-positive leukemia cells | Huang, C.H., Lee, Y.C., Chiou, J.T., Shi, Y.J., Wang, L.J., Chang, L.S. | Toxicology and Applied Pharmacology |
| 2020-04 | 期刊論文 | Status of Asp29 and Asp40 in the interaction of Naja atra cardiotoxins with lipid bilayers | Wu G.L., Shi, Y.J., Huang, C.H., Lee, Y.C., Wang, L.J., Chiou, C.T., Lu, C.Y., Chang, L.S. | Toxins |
| 2020-02 | 期刊論文 | SIRT3, PP2A, and TTP protein stability in the presence of TNF-α on vincristine-induced apoptosis of leukemia cells | Wang, L.J., Chiou, J.T., Lee, Y.C., Huang, C.H., Shi, Y.J., Chang, L.S. | Journal of Cellular and Molecular Medicine |
| 2020-01 | 期刊論文 | utophagic HuR mRNA degradation induces survivin and MCL1 downregulation in YM155-treated human leukemia cells | Chiou, J.T., Lee, Y.C., Huang, C.H., Shi. Y.J., Wang, L.J., Chang, L.S. | Toxicology and Applied Pharmacology |
| 2019-09 | 期刊論文 | utophagic HuR mRNA degradation induces survivin and MCL1 downregulation in YM155-treated human leukemia cells | Chiou, J.T., Shi, Y.J., Wang, L.J., Huang, C.H., Lee, Y.C., Chang, L.S. | Toxins |
| 2019-09 | 期刊論文 | Naja atra cardiotoxins enhance the protease activity of chymotrypsin | Shi, Y.J., Huang, C.H., Lee, Y.C., Wang, L.J., Chiou, J.T., Chang, L.S. | International Journal of Biological. Macromolecules |
| 2019-04 | 期刊論文 | Non-mitotic effect of albendazole triggers apoptosis of human leukemia cells via SIRT3/ROS/p38 MAPK/TTP axis-mediated TNF-α upregulation | Wang, L.J., Lee, Y.C., Huang, C.H., Shi, Y.J., Chen, Y.J., Pei, S.N., Chou, Y.W., Chang, L.S. | Biochemical Pharmacology |
| 2018-09 | 期刊論文 | ABT-263-induced MCL1 upregulation depends on autophagy-mediated 4EBP1 downregulation in human leukemia cells | Lee, Y.C., Wang, L.J., Huang, C.H., Shi, Y.J. and Chang, L.S. | Cancer letters |
| 2018-09 | 期刊論文 | The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells | Chen, Y.J., Huang, C.H., Shi, Y.J., Lee, Y.C., Wang, L.J. and Chang, L.S. | Toxicology and Applied Pharmacology |
| 2018-03 | 期刊論文 | A turn-on fluorescence sensor for heparin detection based on a release of Taiwan cobra cardiotoxin from a DNA aptamer or adenosine-based molecular beacon | Shi, Y.J., Wang, L.J., Lee, Y.C., Huang, C.H., Hu, W.P. and Chang, L.S. | Molecules |
| 2018-02 | 期刊論文 | Membrane-damaging activities of mannosylated ovalbumin are involved in its antibacterial action | Shi, Y.J., Wang, R.T., Chu, Y.H., Chen, Y.J., Tang, C.C., Fu, Y.S., Lee, Y.C., Wang, L.J., Huang, C.H. and Chang, L.S. | Archives of Biochemistry and Biophysics |
| 2017-10 | 期刊論文 | Photodynamic therapy using indolines-fused-triazoles induces mitochondrial apoptosis in human non-melanoma BCC cells | Hu, W.P., Kuo, K.K,, Senadi, G.C., Chang, L.S. and Wang, J.J. | Anticancer Research |
| 2017-09 | 期刊論文 | Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR-183/beta-TrCP/SP1 axis-mediated BAX upregulation | Huang, C.H., Lee, Y.C., Chen, Y.J., Wang, L.J., Shi, Y.J. and Chang, L.S. | Toxicology and Applied Pharmacology |
| 2017-07 | 期刊論文 | Ovalbumin with glycated carboxyl groups shows membrane-damaging activity | Tang, C.C., Shi, Y.J., Chen, Y.J. and Chang, L.S. | International Journal of Molecular Sciences |
| 2017-04 | 期刊論文 | Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1 | Lee, Y.C., Chen, Y.J., Huang, C.H. and Chang, L.S. | Apoptosis |
| 2017-03 | 期刊論文 | Detection of Naja atra cardiotoxin using adenosine-based molecular beacon | Shi, Y.J., Chen, Y.J., Hu, W.P. and Chang, L.S. | Toxins |
| 2017-02 | 期刊論文 | Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells | Chen, Y.J., Liu, W.H. and Chang, L.S. | Archives of Toxicology |
| 2016-09 | 期刊論文 | Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells | Chen, Y.J., Lee, Y.C., Huang, C.H., Chang, L.S. | Toxicology and Applied Pharmacology |
| 2016-07 | 期刊論文 | Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells | Chen, Y.J., Lin, K.N., Jhang, L.M., Huang, C.H., Lee, Y.C., Chang, L.S. | Chemico-Biological Interactions |
| 2016-04 | 期刊論文 | Design, synthesis and antimetastatic evaluation of 1-benzothiazolyl- phenylbenzotriazoles for photodynamic therapy in oral cancer cells | Senadi, G.C., Liao, C.M., Kuo, K.K., Lin, J.C., Chang, L.S., Wang, J.J., Hu, W.P. | Medicinal Chemical Communications |
| 2016-03 | 期刊論文 | DNA aptamers against Taiwan banded krait α-bungarotoxin recognize Taiwan cobra cardiotoxins | Chen, Y.J., Ysai, C.Y., Hu, W.P., Chang. L.S. | Toxins |
| 2016-02 | 期刊論文 | Cardiotoxin III Inhibits Hepatocyte Growth Factor-Induced Epithelial-Mesenchymal Transition and Suppresses Invasion of MDA-MB-231 Cells. | Tsai, P.C., Fu, Y.S., Chang, L.S., Lin, S.R. | Journal of Biochemistry and Molecular Toxicology |
| 2016-01 | 期刊論文 | Taiwan cobra cardiotoxin III suppresses EGF/EGFR-mediated epithelial-to-mesenchymal transition and invasion of human breast cancer MDA-MB-231 cells | Tsai, P.C., Fu, Y.S., Chang, L.S., Lin, S.R. | Toxicon |
| 2016-01 | 期刊論文 | The association between p38 MAPK-mediated TNF-α/TNFR2 up-Regulation and 2-(4-aminophenyl)-7-methoxybenzothiazole-induced apoptosis in human leukemia U937 cells. | Huang, C.H., Chen, Y.J., Chao, T.Y., Liu, W.H., Changchien, J.J., Hu, W.P., Chang, L.S. | Journal of Cellular Physiology |
| 2015-10 | 期刊論文 | NFκB- and AP-1-mediated DNA looping regulates matrix metalloproteinase-9 transcription in TNF-α-treated human leukemia U937 cells. | Chen, Y.J., Chang, L.S. | Biochimica et Biophysica Acta-Gene Regulatory Mechanism |
| 2015-03 | 期刊論文 | Antibacterial and membrane-damaging activities of mannosylated bovine serum albumin. | Tsai, C.Y., Chen, Y.J., Fu, Y.S., Chang, L.S. | Archives Biochemistry Biophysics |
| 2015-02 | 期刊論文 | Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression. | Changchien, J.J., Chen, Y.J., Huang, C.H., Cheng, T.L., Lin, S.R., Chang, L.S. | Toxicology and Applied Pharmacology |
| 2014-12 | 期刊論文 | Simvastatin induces NFkB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells | Chen, Y.J. and Chang, L.S. | Biochemical Pharmacology |
| 2014-09 | 期刊論文 | Modulated mechanism of phosphatidylserine on the catalytic activity of Naja naja atra phospholipase A2 and Notechis scutatus scutatus notexin | Chiou, Y.L., Lin, S.R., Hu, W.P., Chang, L.S. | Toxicon |
| 2014-08 | 期刊論文 | Bovine serum albumin with glycated carboxyl groups shows membrane-perturbing activities. | Yang, S.Y., Chen, Y.J., Kao, P.S., Chang, L.S. | Archives of Biochemistry and Biophysics |
| 2014-05 | 期刊論文 | Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells | Chen, Y.J., Lin, H.C., Chen, K.C., Lin, S.R., Cheng, T.L., Chang, L.S. | Toxicon |
| 2014-04 | 期刊論文 | Cardiotoxin III suppresses hepatocyte growth factor-stimulated migration and invasion of MDA-MB-231 cells. | Tsai, P.C., Chu, C.L., Chiu, C.C., Chang, L.S., Lin, S.R. | Cell Biochemistry and Function |
| 2014-03 | 期刊論文 | Inhibitory action of naphtho[1,2-b]furan-4,5-dione on hepatocyte growth factor-induced migration and invasion of MDA-MB-231 cells | Tsai, P.C., Chu, C.L., Tseng, C.H., Chen, Y.L., Chang, L.S., Lin, S.R. | Clinical and Experimental Pharmacololy and Physiology |
| 2014-02 | 期刊論文 | Naphtho[1,2-b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways | Tsai, P.C., Chu, C.L., Fu, Y.S., Tseng, C.H., Chen, Y.L., Chang, L.S., Lin, S.R. | Molecular and Cellular Biochemistry |
| 2014-01 | 期刊論文 | Amsacrine suppresses matrix metalloproteinase-2 (MMP-2)/MMP-9 expression in human leukemia cells. | Liu, W.H., Chen, Y.J., Chien, J.H. and Chang L.S. | Journal of Cellular Physiology |
| 2013-10 | 期刊論文 | Inhibition of Src activation with cardiotoxin III blocks migration and invasion of MDA-MB-231 cells. | Tsai, P.C., Chu, C.L., Chiu, C.C., Chang, L.S., Lin SR. | Toxicon |
| 2013-10 | 期刊論文 | Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length. | Cheng, T.C., Chuang, K.H, Chen, M., Wang, H.E., Tzou, S.C., Su, Y.C., Chuang, C.H., Kao, C.H., Chen, B.M., Chang, L.S., Roffler, S.R., Cheng, T.L. | Bioconjugation Chemistry |
| 2013-10 | 期刊論文 | Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c] [1,4]benzodiazepines hybrid scaffolds. | Chen, C.Y., Lee, P.H., Lin, Y.Y., Yu, W.T., Hu, W.P., Hsu, C.C., Lin, Y.T., Chang, L.S., Hsiao, C.T., Wang, J.J., Chung, M.I. | Bioorganic and Medical Chemistry Letters |
| 2013-09 | 期刊論文 | Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-alpha production in human leukemia cells with expressed Bcr/Abl | Chen, Y.J., Chang L.S. | Biochemical Pharmacology |
| 2013-08 | 期刊論文 | NMR Solution Structure of a Chymotrypsin Inhibitor from the Taiwan Cobra Naja naja atra | Lin, Y.J., Ikeya, T., Güntert, P., Chang. L.S. | Molecules |
| 2013-06 | 期刊論文 | Brazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells | Hsieh, C.Y., Tsai, P.C., Chu, C.L., Chang, F.R., Chang, L.S., Wu, Y.C., Lin, S.R. | Chemico-Biological Interaction |
| 2013-05 | 期刊論文 | Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit alpha and MAPK phosphatase-1 expression in human leukemia U937 cells | Liu, W.H., Chen, Y.J., Cheng, T.L., Lin, S.R., Chang, L.S. | Cellular Signaling |
| 2013-05 | 期刊論文 | DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways | Chen, C.Y., Chen, Y.K., Wang, J.J., Hsu, C.C., Tsai, F.Y., Sung, P.J., Lin, H.C., Chang, L.S., Hu, W.P. | Cell Biology and Toxicology |
| 2013-03 | 期刊論文 | Fusogenicity of Naja naja atra cardiotoxin-like basic protein on sphingomyelin vesicles containing oxidized phosphatidylcholine and cholesterol | Kao, P.H., Chen, Y.J., Yang, S.Y., Lin, S.R., Hu, W.P., Chang, L.S. | Journal of Biochemistry |
| 2013-03 | 期刊論文 | p38 MAPK/PP2Acalpha/TTP pathway on the connection of TNF-alpha and caspases activation on hydroquinone-induced apoptosis | Liu, W.H., Chou, W.M., Chang, L.S. | Carcinogenesis |
| 2013-02 | 期刊論文 | Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells | Hsieh, C.Y., Tsai, P.C., Tseng, C.H., Chen, Y.L., Chang, L.S., Lin, S.R. | Toxicology In Vitro |
| 2013-01 | 期刊論文 | Antibacterial and membrane-damaging activities of beta-bungarotoxin B chain | Wen, Y.L., Wu, B.J., Kao, P.S., Fu, Y.S., Chang, L.S. | Journal of Peptide Science |
| 2012-12 | 期刊論文 | A regularly-spaced and self-revealing protein ladder for anti-tag western blot analysis | Kao, C.H., Cheng, C.M., Chuang, K.H., Chuang, C.H., Tzou, S.C., Cheng, T.C., Hsieh, Y.C., Liao, K.W., Wang. Y.M., Chang, L.S., Roffler, S.R., Chen, F.M., Cheng, T.L. | Analytical Chemistry |
| 2012-12 | 期刊論文 | CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability | Liu, W.H., Chen, Y.L., Chang, L.S. | The International Journal of Biochemistry & Cell Biology |
| 2012-12 | 期刊論文 | Furano-1,2-Naphthoquinone Inhibits src and pi3k/akt Signaling Pathways in ca9-22 Human Oral Squamous Carcinoma Cells | Lin, K.L., Chien, C.M., Tseng, C.H., Chen, Y.L., Chang, L.S., Lin, S.R. | Integrative Cancer Therapy |
| 2012-10 | 期刊論文 | Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway | Tsai, P.C., Hsieh, C.Y., Chiu, C.C., Wang, C.K., Chang, L.S., Lin, S.R. | Toxicon |
| 2012-09 | 期刊論文 | Gallic acid down-regulates matrix metalloproteinase-2 (MMP-2) and MMP-9 in human leukemia cells with expressed Bcr/Abl | Chen, Y.J., Chang, L.S. | Molecular Nutrition and Food Research |
| 2012-09 | 期刊論文 | Naja naja atra and Naja nigricollis cardiotoxins induce fusion of Escherichia coli and Staphylococcus aureus membrane-mimicking liposomes | Kao, P.S., Lin, S.R.., Hu, W.P., Chang, L.S. | Toxicon |
| 2012-09 | 期刊論文 | Suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNFalpha-mediated NFkB activation in piceatannol-treated human leukemia U937 cells | Liu, W.H., Chang, L.S. | Biochemical Pharmacology |
| 2012-06 | 期刊論文 | Quercetin modulates activities of Taiwan cobra phospholipase A2 via its effects on membrane structure and membrane-bound mode of phospholipase A2 | Chiou, Y.L., Lin, S.R., Hu, W.P., Chang, L.S. | Journal of Biosciences |
| 2012-05 | 期刊論文 | Arecoline-induced death of human leukemia K562 cells is associated with surface up-modulation of TNFR2 | Chen, Y.J., Chang, L.S. | Journal of Cellular Physiology |
| 2012-01 | 期刊論文 | Antimetastatic potential of cardiotoxin III involves inactivation of PI3K/Akt and p38 MAPK signaling pathways in human breast cancer MDA-MB-231 cells | Lin, K.L., Chien, C.M., Hsieh, C.Y., Tsai, P.C., Chang, L.S., Lin, S.R. | Life Sciences |
| 2012-01 | 期刊論文 | Guanidination of notexin promotes its phospholipase A2 activity-independent fusogenicity on vesicles with lipid-supplied negative curvature | Kao, P.H. Chiou, Y.L., Chen, Y.J., Lin S.R., Chang L.S. | Toxicon |
| 2011-12 | 期刊論文 | Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway | Liu, W.H., Chang, L.S. | The International Journal of Biochemistry & Cell Biology |
| 2011-11 | 期刊論文 | Adaphostin promotes caffeine-evoked autoacrine Fas-mediated death pathway activation in Bcr/Abl-positive leukemia cells | Liu, W.H., Chang, L.S. | Biochemical Journal |
| 2011-11 | 期刊論文 | Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells | Lin, K.L., Tsai, P.C., Hsieh, C.Y., Chang, L.S., Lin SR. | Chemico-Biological Interactions |
| 2011-11 | 期刊論文 | Naja nigricollis CMS-9 enhances mitochondria-mediated death pathway in adaphostin-treated human leukemia U937 cells | Chen, Y.J., Wang, J.J., Chang, L.S. | Clinical and Experimental Pharmacology and Physiology |
| 2011-11 | 期刊論文 | Phospholipase A2 activity-dependent and -independent fusogenic activity of Naja nigricollis CMS-9 on zwitterionic and anionic phospholipid vesicles | Chiou, Y.L., Chen, Y.J., Lin, S.R., Chang, L.S. | Toxicon |
| 2011-09 | 期刊論文 | A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling | Hsieh, M.C., Hu, W.P., Yu, H.S., Wu, W.C., Chang, L.S., Kao, Y.H., Wang, J.J. | Toxicology and Applied Pharmacology |
| 2011-08 | 期刊論文 | Bactericidal effect of Naja nigricollis toxin gamma is related to its membrane-damaging activity | Chen, L.W., Kao, P.H., Fu, Y.S., Hu, W.P., Chang, L.S. | Peptides |
| 2011-07 | 期刊論文 | Sphingomyelin modulates interfacial binding of Taiwan cobra phospholipase A2 | Chiou, Y.L., Lin, S.R., Chang, L.S. | Chemistry and Physics of Lipids |
| 2011-06 | 期刊論文 | Membrane-damaging activity of Taiwan cobra cardiotoxin 3 is responsible for its bactericidal activity | Chen, L.W., Kao, P.H., Fu, Y.S., Lin, S.R., Chang, L.S. | Toxicon |
| 2010-12 | 期刊論文 | Guanidination of notexin alters its membrane-damaging activity in response to sphingomyelin and cholesterol | Kao, P.H., Chiou, Y.L., Lin, S.R., Chang, L.S. | Journal of Biosciences |
| 2010-12 | 期刊論文 | Lipid domain formation modulates activities of snake venom phospholipase A2 enzymes | Chiou, Y.L., Lin, S.R., Chang, L.S. | Toxicon |
| 2010-10 | 期刊論文 | Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells | Su, J.C., Lin, K.L., Chien, C.M., Tseng, C.H., Chen, Y.L., Chang, L.S., Lin S.R. | Cellular ad Biochemical Function |
| 2010-10 | 期刊論文 | Suppression of ADAM17-mediated Lyn/Akt pathways induces apoptosis of human leukemia U937 cells: Bungarus multicinctus protease inhibitor-like protein-1 uncovers the cytotoxic mechanism | Liu, W.H., Chang, L.S. | Journal of Biological Chemistry |
| 2010-09 | 期刊論文 | Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway | Liu, W.H., Chang, L.S. | Journal of Cellular Physiology |
| 2010-09 | 期刊論文 | Piceatannol induces Fas and FasL up-regulation in human leukemia U937 cells via Ca2+/p38aalpha MAPK-mediated activation of c-Jun and ATF-2 pathways | Liu, W.H., Chang, L.S. | The International Journal of Biochemistry & Cell Biology |
| 2010-09 | 期刊論文 | Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells | Chien, C.M., Chang, S.Y., Lin, K.L., Chiu, C.C., Chang, L.S., Lin, S.R. | Toxicon |
| 2010-09 | 期刊論文 | Taiwan cobra phospholipase A2 elicits posttranscriptional up-regulation of ADAM17 in human neuroblastoma SK-N-SH cells | Liu, W.H., Chen. K.C., Chiou, Y.L., Lin, S.R., Chang, L.S. | Journal of Cellular Biochemistry |
| 2010-08 | 期刊論文 | Concomitant inactivation of the EGFR, PI3K/Akt, and JAK2/STAT3 signaling pathways in cardiotoxin III-treated A549 cells | Su, J.C., Lin, K.L., Chien, C.M., Chuang, P.W., Chang, L.S., Lin, S.R. | Clinical and Experimental Pharmacology and Physiolology |
| 2010-08 | 期刊論文 | Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents | Hu, W.P., Chen, Y.K., Liao, C.C., Yu, H.S., Tsai, Y.M., Huang, S.M., Tsai, F.Y., Shen, H.C., Chang, L.S., Wang, J.J. | Bioorganic and Medicinal Chemistry |
| 2010-06 | 期刊論文 | Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells | Lin, K.L., Su, J.C., Chien, C.M., Chuang, P.W., Chang, L.S., Lin, S.R. | Toxicon |
| 2010-06 | 期刊論文 | Interaction of Naja naja atra cardiotoxin 3 with H-trisaccharide modulates its hemolytic activity and membrane-damaging activity | Kao. P.H., Lin, S.R., Chang, L.S. | Toxicon |
| 2010-06 | 期刊論文 | Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells | Chen, Y.J., Liu, W.H., Kao, P.S., Wang, J.J., Chang, L.S. | Toxicon |
| 2010-06 | 期刊論文 | Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells | Lin, K.L., Su, J.C., Chien, C.M., Tseng, C.H., Chen, Y.L., Chang, L.S., Lin, S.R. | Toxicology In Vitro |
| 2010-06 | 期刊論文 | Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: Involvement of EGF receptor/PI3K/Akt signaling pathway. | Chien, C.M., Lin, K.L., Su, J.C., Chuang, P.W., Tseng, C.H., Chen, Y.L., Chang, L.S., Lin, S.R. | European Journal of Pharmacology |
| 2010-04 | 期刊論文 | Notexin upregulates Fas and FasL protein expression of human neuroblastoma SK-N-SH cells through p38 MAPK/ATF-2 and JNK/c-Jun pathways | Chen, K.C., Chang, L.S. | Toxicon |
| 2010-03 | 期刊論文 | Suppression of ERK signaling evokes autocrine Fas-mediated death in arachidonic acid-treated human chronic myeloid leukemia K562 cells | Chen, K.C., Liu, W.H., Chang, L.S. | Journal of Cellular Physiology |
| 2010-02 | 期刊論文 | Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation | Lin, K.L., Su, J.C., Chien, C.M., Tseng, C.H., Chen, Y.L., Chang, L.S., Lin, S.R. | Toxicology In vitro |
| 2010-02 | 期刊論文 | Roles of lysine residues and N-terminal alpha-amino group in membrane-damaging activity of Taiwan cobra cardiotoxin 3 toward anionic and zwitterionic phospholipid vesicles | Chiou, Y.L., Kao, P.H., Liu, W.H., Lin, S.R., Chang, L.S. | Toxicon |
| 2010-02 | 期刊論文 | Structure-function studies on inhibitory activity of Bungarus multicinctus protease inhibitor-like protein on matrix metalloprotease-2, and invasion and migration of human neuroblastoma SK-N-SH cells | Chou, W.M., Liu, W.H., Chen, K.C., Chang, L.S. | Toxicon |
| 2010-01 | 期刊論文 | Calcium-stimulated mitogen-activated protein kinase activation elicits Bcl-xL downregulation and Bak upregulation in notexin-treated human neuroblastoma SK-N-SH cells | Chen, K.C., Liu, W.H., Kao, P.S., Chang, L.S. | Journal of Cellular Physiology |
| 2010-01 | 期刊論文 | Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells | Su, J.C., Lin, K.L., Chien, C.M., Tseng, C.H., Chen, Y.L., Chang, L.S., Lin, S.R. | Life Sciences |
| 2010-01 | 期刊論文 | Taiwan cobra phospholipase A2-elicited JNK activation is responsible for autocrine Fas-mediated cell death and modulating Bcl-2 and Bax protein expression in human leukemia K562 cells | Chen, K.C., Liu, W.H., Chang, L.S. | Journal of Cellular Biochemistry |
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