專利/Patent
1. Sheu JJC, Chang C, Lin BC, Yang LY, Lai YJ 
Method, kit and computer-implemented method for predicting survival time of individual with bladder cancer after surgery from individual’s biological sample
由個體之生物學試樣預測個體膀胱癌術後存活時間的方法、套組及電腦執行方法
TW Patent: I820582 (2023.11.01 – 2042.01.20)
U.S. Patent Application: 18/146,571

2. Sheu JJC, Chang CYY, Chen CM    
Kit for in vitro testing panel of genes in pap smear samples for endometriosis and method of non-invasively and qualitatively determining severity of endometriosis using the kit
體外篩檢巴氏抹片樣本之子宮內膜異位症基因集的套組及其用於非侵入式定性判斷子宮內膜異位症惡化程度的方法
TW Patent: I825376 (2023.12.11 – 2040.12.23)
U.S. Patent Application: 16/726,546
EU Patent Application: EP20215357.3
CN Patent Application: CN202011555278.7

3. Sheu JJC, Chang CYY, Chaing AJ, Chen CM    
Medicinal composition for alleviating endometriosis and complications thereof and use of the same
減緩子宮內膜異位症及其併發症之醫藥組成物及其用途
U.S. Patent Application: 15/705,235
TW Patent: I700094 (2020.08.01 – 2037.09.13)

4. Sheu JJC, Chang CYY, Chen CM    
Biomarker of detecting a biological sample, probe kit and method of non-invasively and qualitatively determining severity of endometriosis
用於偵測生物樣本的生物標記、探針、套組及其用於非侵入式定性判斷子宮內膜異位症惡化程度的方法
U.S. Patent Application: 15/704004
TW Patent: I651414 (2019.02.21 - 2037.09.13)

5. Sheu JJC, Chang CYY, Chaing AJ, Chen CM
Method of treating endometriosis and endometriosis-associated ovarian cancers
U.S. Provisional-Patent 62394219 filed on Sep 14/2016

6. Sheu JJC, Tsai FJ, Cheng J, Chao SJC
Method for in vitro detecting keratin gene fusion of squamous-cell cancer
活體外檢測鱗狀細胞癌的方法
Taiwan (R.O.C.) Patent Number: I468519 issued on Jan 11/2015.
U.S. Patent Application: 2013785829.

7. Sheu JJC, Chang YL, Chen TS, Liou SY
Composition of Chinese medicine recipes for cancer therapy
Taiwan (R.O.C.) Patent Application: 201119663.

8. Chang TW, Sheu JJC, Lo LH, Chen NY, Lin YS.
Recombinant enterovirus 71 neutralizing antibodies and applications thereof
Hong Kong Patent Application: 1099312.
Taiwan (R.O.C.) Patent Number: I296930 issued on May 21, 2008.
U.S. Patent Number: 7,482,006 issued on Jan 27, 2009.
China Patent Number: 100513424C issued on July 15, 2009.

9. Chang TW, Sheu JJC, Huang JSW, Wu SCS, Chen LYY.
Composition and methods for induction of active autoimmunity.
U.S. Patent Application: 09852976.

專書/Book Chapter
Chang CYY, Chang HW, Chen CM, Lin CY, Chen CP, Lai CH, Lin WY, Liu HP, Sheu JJ*, Tsai FJ* (2019) MUC4 gene polymorphisms associate with endometriosis development and infertility. Top-5 Contributions in Medical Research, Chapter V by Avid Science

請見學術檔案聯結  Pls visit the Google Scholar link

 執行中/ On going projects

1. PI / Impacts of alterations in cytoskeleton networks on cell fate determination and tumor microenvironment remodeling (NSTC 112-2320-B-110 -005 -MY3)
2. Co-PI / Clinical validation and functional characterization of TCM syndrome differentiation/treatments on irregular menstruation (2) (NSTC 111-2320-B-039-030-MY3; 2022.08-2025.07)

執行完成計畫 / Finished projects
As a PI

1. MOST Germination Program: Non-invasive rapid screening method for gynecological disorders (2020.09.01-2020.12.31)
2. Novel keratin fusions alter mechanical properties of cancer cells and promote cancer aggressiveness (MOST 109-2314-B-110-003-MY3; 2020.08-2023.07)
3. Using ribosome biogenesis as a therapeutic target for treating endometriosis and the associated complications (106WGEFA0800003; 2018.03-2021.02) (Cost Share Programme with Royal Society, UK) Bilateral Traveling Funds to Prof. E Greave’s Lab, Edinburgh Univ, UK
4. Biological functions of novel keratin fusions in cancer stem cell development (MOST- 106-2314-B-110-001-MY3; 2017.08-2020.07) Bilateral MAGIC Add-On project to Prof. D Riveline’s Lab, IGMBC, France
5. Rapid DNA collection/purification and cancer recurrence prognosis using the urine from patients with bladder cancer (MOST 105-2622-B-110-001-CC2; 2016.06-2017.05)
6. The biological functions of nuclear VCP interactome in oral squamous cell carcinoma development (MOST 103-2314-B-039-009-MY3; 2013.08-2016.07)
7. Novel keratin fusions in squamous cell carcinoma development (2) (NSC-102-2628 -B-039-001-MY3; 2013.08-2016.07)
8. Novel keratin fusions in squamous cell carcinoma development (NSC-101-2320-B-039-006-; 2012.08-2013.07)
9. Chromatin remodeling factor Rsf-1 triggers genome instability during cancer development (NSC-98-2320-B-039-033-MY3; 2009.08-2012.07)
10. Recombinant human neutralizing Abs against SARS-CoV (The SARS Research Program, SDRU19; 2003.11-2004.04)

As a Co-PI

1. Clinical validation and functional characterization of TCM syndrome differentiation/treatments on irregular menstruation (MOST 110-2320-B-039-033-; 2021.08-2022.07)
2. Malignant transition of oral lesions in betel nut chewer: betel nut-genome interaction and its effects on metabolism (MOST 104-2314-B-037-040-; 2015.08–2016.07)
3. Bioinformatics tools for fusion protein interaction and epigenetic-regulated microRNA pathway in cancer biology (NSC-102-2221-E-468-024-; 2013.08-2014.07)
4. The inhibitory effects of type-1 interferon on cell growth: the functional roles of STAT6 (NSC-98-2320-B-039-008-MY3; 2009.08-2012.07)
5. Mechanism study of enterovirus-71 infection using genomic and proteomic approaches: the anti-viral effects of kaempferol and bioflavonoids (NSC-97-2320-B-039-023-MY3; 2008.08-2011.07)
6. Signal transduction of the genetic variant of human growth hormone receptor (codon 440 G/T) (NSC-96-2314-B-039-006-MY3; 2007.08-2010.07)