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鄭光宏 教授兼生醫所所長

鄭光宏

專長領域：胰臟癌研究、癌症幹細胞研究、幹細胞生物學、幹細胞訊息傳遞

聯絡電話：07-5252000分機:7107、7114

E-mail:khcheng@faculty.nsysu.edu.tw

學歷
1992 高雄醫學院醫技系學士
1995 中興大學分子生物研究所碩士
2003 美國波士頓大學醫學院病理博士
經歷
2004 - 2005 美國波士頓大學附設醫學院博士後研究員
2005 - 2007 美國哈佛醫學院附設麻州總醫院癌症中心博士後研究員
2007 - 2008 美國哈佛醫學院附設柏雷根婦女醫院博士後研究員
2008 - 2014 中山大學生物醫學所助理教授
2014- 2019 中山大學生物醫學所副教授
  2019- 中山大學生物醫學所教授
研究領域
1.Pancreatic cancer research
2.Cancer biology
3.Cancer stem cell research
4.Stem cell biology
5.Stem cell signal transduction
專利
  Method of determining gene expression-Targeted Expressed Gene Display- application pending U.S.S.N 60/457,472:BU03-16, Boston University. USA
  A novel loss of heterozygoisity (LOH) analysis method -Dilution End point LOH Analysis (DELA)- application pending, Boston University, USA
  新式專利　檢測女性癌症之裝置- 台灣 1479-NCSU-TW　發明人　鄭光宏 2013/11 至 2016/11
  台灣專利  苦楝花粗粹液保肝及/或治療癌症的功效 台灣專利第101107069號  發明人　鄭光宏 翁靖傑 蘇惠庭 2014/12 至 2017/12
  台灣專利  居家使用簡易型糞便早期篩檢胰臟癌的檢測模組 台灣專利申請中 發明人　鄭光宏 郭子雷 翁靖傑 郭功楷
學術榮譽
2008 Ruth L. Kirschstein National Research Service Award Fellowship (2nd year), USA
2007 Program of Excellence Award, the Ovarian Cancer Research Fund, Inc., USA
2007 Ruth L. Kirschstein National Research Service Award Fellowship, USA
2004 10th Russek Student Achievement Awards (Honorable Mention), Boston University School of Medicine, USA
2003 Best Poster Award, First Annual Retreat, Department of Genetics and Genomics, Boston University School of Medicine, USA
學術著作

出版年月 著作類別 著作名稱 作者 收錄出處
2020 期刊論文 Inhibition of b-catenin activity abolishes LKB1 loss driven pancreatic cystadenoma in mice. Hsieh MJ, Weng CC, Lin YC, Wu CC, Chen LZ,* and KH Cheng  本人為共同通訊作者 Int J Mol Sci.
2020 期刊論文 Inactivation of APC induces CD34 upregulation to promote epithelial-mesenchymal transition and cancer stem cell traits in pancreatic cancer Hsieh MJ, Chiu TJ,  Lin YC, Weng CC, Weng YT, Hsiao CC,* and KH Cheng 本人為通訊作者 Int J Mol Sci.
2019 期刊論文 The use of genetically engineered mouse models for studying the function of mutated driver genes in pancreatic cancer. Weng CC, Lin YC, Cheng KH. 本人為通訊作者 J Clin Med.
2019 期刊論文 Low-energy extracorporeal shock wave therapy ameliorates kidney function in diabetic nephropathy. Hsiao CC, Huang WH, Cheng KH, Lee CT. Oxid Med Cell Longev
2019 期刊論文 Deciphering The Potential Role of Hox Genes in Pancreatic Cancer. Kuo TL, Cheng KH, Chen LT, Hung WC. Cancers (Basel).
2019 期刊論文 Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven Development of pancreatic cancer.  Weng CC, Hsieh MJ, Wu CC,  Lin YC, Chen LZ, Hung WC, Cheng KH.  本人為通訊作者 Mol Cancer.
2019 期刊論文 β-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer. Kuo TL, Cheng KH, Shan YS, Chen LT, Hung WC. Theranostics.
2019 期刊論文 MAL-PDT inhibits oral precancerous cells and lesions via autophagic cell death. Wang YY, Chen YK, Hu CS, Xiao LY, Huang WL, Chi TC, Cheng KH, Wang YM, Yuan SF. Oral Dis. 
2019 期刊論文 Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis.  Weng CC, Ding PY, Liu YH, Hawse JR, Subramaniam M, Wu CC, Lin YC, Chen CY, Hung WC, Cheng KH.  本人為共同通訊作者 Oncogene.
2018-12 期刊論文 K-ras and p53 promotes PDGF/Src-dependent growth and metastasis in pancreatic cancer T-L. Kuo , K-H. Cheng , Y-S. Shan , L-T. Chen , W-C. Hung Theranostics
2018-12 期刊論文 Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis. Weng C-C*, P-Y Ding*, Y-H Liu, John R. Hawse, Malayannan Subramaniam, C-C Wu, Y-C Lin, C-Y Chen, W-C Hung, K-H Cheng Oncogene
2017-09 期刊論文 KLF10 loss in the pancreas provokes activation of SDF-1 and induces distant metastases of pancreatic ductal adenocarcinoma in the KrasG12D p53flox/flox model. C-C., Weng, H-S., Vincent, Chang, SA. Johnsen, M., Subramaniam, Winston C.Y. Yu, C-Y., Chen, W-C., Hung, L.Z., Chen and Cheng, KH Oncogene
2017-04 期刊論文 KRAS mutation coupled with p53 loss is sufficient to induce ovarian carcinosarcomas in mice. Tang FH, Hsieh TH, Hsu CY, Lin HY, Long CY, Cheng KH, Tsai EM. Int J Cancer.
2017-04 期刊論文 WDR4-driven PML destruction fosters immunosuppressive and pro-metastatic lung tumor microenvironment. Wang YT, Jocelyn Chen, C-W Chang, Jayu Jen, T-Y Huang, C-M Chen, Roger Shen, S-Y Liang, I-C Cheng, S-C Yang, W-W Lai, K-H Cheng, T-S Hsieh, M-Z Lai, H-C Cheng, Y-C Wang, R-H Chen J Clin Invest.
2016-05 期刊論文 Suppression of IL8-Src Signaling Axis by 17β-Estradiol Inhibits Human Mesenchymal Stem Cells-Mediated Gastric Cancer Invasion. Liu, C-J., Kuo, F-C., Wang, C-L., Kuo, C-H., Sophie S.W. Wang, Chen, C-Y., Hunag, Y-B., Cheng, K-H., Yokoyama, K., Chen, C-L., Ku, C-Y., Wu, D-C J. Cell. Mol. Med
2016-04 期刊論文 APC haploinsufficiency coupled with P53 loss is sufficient to induce mucinous cystic neoplasms and invasive pancreatic carcinoma in mice Tzu-Lei Kuo, Ching-Chieh Weng, Kung-Kai Kuo, Chiao-Yun Chen, Deng-Chyang Wu, Wen-Chun Hung, Kuang- Hung Cheng Oncogene
2016-03 期刊論文 Pancreatic tumor progression associated with CD133 overexpression: involvement of increased TERT expression and EGFR-dependent Akt Activation Ching-Chieh Weng*, Kung-Kai Kuo*, Huei-Ting Su, Pi-Jung Hsiao, Yu-Wen Chen, Deng-Chyang Wu, Wen-Chun Hung, Kuang- Hung Cheng Pancreas
2016-01 期刊論文 Quantitative Proteomic Analysis of Differentially Expressed Profiles Involved In the Progression of Pancreatic Ductal Adenocarcinoma Kung Kai Kuo*, Chao Jen Kuo*, Chiang Yen Chiu, Shih Shin Liang, Shu Wen Chi, Kun Bow Tsai, Chiao Yun Chen, Edward Hsi, Kuang Hung Cheng, Shyh Horng Chiou Pancreas
2015-07 期刊論文 Epigenetic Inactivation of TGFbeta1 Target Gene HEYL, a Novel Tumor Suppressor, Involved in the P53 Induced Apoptotic Pathway in Hepatocellular Carcinoma. Kung-Kai Kuo*, Shu-Fang Jian*, Yi-Jin Li, Shih-Wei Wan, Ching-Chieh Weng, Kuan Te Fang, Deng-Chyang Wu and Kuang- Hung Cheng Hepatology Research
2014-07 期刊論文 17β-Estradiol inhibition of IL-6-Src and Cas and paxillin pathway suppresses human mesenchymal stem cells-mediated gastric cancer cell motility Liu CJ, Kuo FC, Hu HM, Chen CY, Huang YB, Cheng KH, Yokoyama KK, Wu DC, Hsieh S, Kuo CH. Translation Research
2014-07 期刊論文 Effects of Antidepressants on IP-10 Production in LPS-Activated THP-1 Human Monocytes. Tsai JH, Kuo CH, Yang P, Cheng KH, Wang PW, Chen CC, Hung CH. Int J Mol Sci.
2014-05 期刊論文 Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Chu TH, Chan HH, Kuo HM, Liu LF, Hu TH, Sun CK, Kung ML, Lin SW, Wang EM, Ma YL, Cheng KH, Lai KH, Wen ZH, Hsu PI, Tai MH. Oncotarget
2014-04 期刊論文 SMAD4 Loss Triggers the Phenotypic Changes of Pancreatic Ductal Adenocarcinoma Cells Yu-Wen Chen, Pi-Jung Hsiao, , Ching-Chieh Weng, Kung-Kai Kuo, Tzu-Lei Kuo, Deng-Chyang Wu, Wen-Chun Hung, Kuang-Hung Cheng BMC Cancer
2014-04 期刊論文 Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1-APC Interaction in Modulating Wnt/β-Catenin Pathway of Lung Cancer Cells Shu-Fang Jian, Chang-Chun Hsiao, Shin-Yi Chen, Ching-Chieh Weng, Tzu-Lei Kuo, Deng-Chyang Wu, Wen-Chun Hung and Kuang-Hung Cheng Molecular Cancer Research
2014-02 期刊論文 Activation of VCAM-1 and Its Associated Molecule CD44 Leads to Increased Malignant Potential of Breast Cancer Cells Pei-Chen Wang+, Ching-Chieh Weng+, You-Syuan Hou, Shu-Fang Jian, Kuan-Te Fang , Ming-Feng Hou and Kuang-Hung Cheng International Journal of Molecular Sciences
2013-12 期刊論文 Semiconductor Nanomaterials-Based Fluorescence Spectroscopic and Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometric Approaches to Proteome Analysis Suresh Kumar Kailasa*, Kuang-Hung Cheng* and Hui-Fen Wu Materials
2013-07 期刊論文 RECK inhibits stemness gene expression and tumorigenicity of gastric cancer cells by suppressing ADAM-mediated Notch1 activation. Hong KJ, Wu DC, Cheng KH, Chen LT, Hung WC. J Cell Physiol.
2013-07 期刊論文 Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer. Su HT, Weng CC, Hsiao PJ, Chen LH, Kuo TL, Chen YW, Kuo KK, Cheng KH Molecular Cancer Research
2013-06 期刊論文 Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. Chiou YS, Sang S, Cheng KH, Ho CT, Wang YJ, Pan MH. Carcinogenesis
2013-02 期刊論文 Association between GABA(A) receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese. Tsai JH, Yang P, Lin HH, Cheng KH, Yang YH, Wu MT, Chen CC. Sleep
2012-10 期刊論文 Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy. McAuliffe SM, Morgan SL, Wyant GA, Tran LT, Muto KW, Chen YS, Chin KT, Partridge JC, Poole BB, Cheng KH, Daggett J Jr, Cullen K, Kantoff E, Hasselbatt K, Berkowitz J, Muto MG, Berkowitz RS, Aster JC, Matulonis UA, Dinulescu DM. Proc Natl Acad Sci U S A.
2012-03 期刊論文 The activation of MEK/ERK signaling pathway by bone morphogenetic protein 4 to increase hepatocellular carcinoma cell proliferation and migration. Chiang-Yen Chiu, Kung-Kai Kuo, Tzu-Lei Kuo, King-The Lee, Kuang-Hung Cheng Molecular Cancer Research
2011-11 專書 BMP signaling in primordial germ cell development and maturation. (2011) H-W. Huang, H-W. Chang, T-L. Kuo, K-H. Cheng (鄭光宏) Book Title: Bone Morphogenetic Proteins: New Research ; Book chapter, Nova Science Publishers
2011-10 期刊論文 Human Adipose-Derived Stem Cells: Isolation; Characterization And Current Application In Regeneration Medicine Kuang-Hung Cheng, Tzu-Lei Kuo, Kung-Kai Kuo, Chang-Chun Hsiao Genomic Medicine, Biomarkers, and Health Sciences
2011-01 期刊論文 Smad4 inactivation promotes malignancy and drug resistance of colorectal cancer. P. Papageorgis, K.H. Cheng, A. W. Lambert1, S.Ozturk1,A. Hamid, J.R. Zhou and S. Thiagalingam*. Cancer Research

 

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