sheu
Jim Jinn-Chyuan Sheu (許晉銓), PhD
Professor
Human Genetic Center
China Medical University Hospital
Institute of BioMedical Sciences
National Sun Yat-sen University
Phone: +886-7-5252000 ext.5811
Fax: +886-7-5250197
Email: sheu.jim@gmail.com
Address: 70 Lienhai Rd., Kaohsiung 80424, TAIWAN
Research interests: cancer genetics and genomics, epigenetics, chromatin remodeling, signal transduction profiling, new drug discovery & development, complementary & alternative medicine, antibody/vaccine engineering
EDUCATIONAL History
1994 B.S. Biology Fu-Jen University TAIWAN
2002 Ph.D. Life Science Tsing-Hua University TAIWAN
PROFESSIONAL EXPERIENCES
Aug 2014 ~ Present Professor/Institute of BioMedical Sciences
National Sun Yat-sen University, Taiwan
Aug 2006 ~ Present Researcher/Human Genetic Center
China Medical University Hospital, Taiwan
Aug 2013 ~ July 2014 Professor/Graduate Institute of Chinese Medical Science
China Medical University, Taiwan
Nov 2009 ~ Jul 2013 Associate Professor/Graduate Institute of Chinese Medical Science
China Medical University, Taiwan
Nov 2006 ~ Oct 2009 Assistant Professor/Graduate Institute of Chinese Medical Science
China Medical University, Taiwan
Sep 2004 ~ Nov 2006 Research Fellow/Department of Pathology and Oncology
Johns Hopkins Medical Institutions, USA
Jun 2004 ~ Sep 2004 Director/Protein Drugs Division
Development Center for Biotechnology, Taiwan
Aug 2003 ~ Jun 2004 Project Leader/BioMedicine Division
Development Center for Biotechnology, Taiwan
Jul 2003 ~ Sep 2004 Visiting Researcher/Dr. Carmay Lim’s Lab
Institute of BioMedical Science, Academia Sinica, Taiwan
Jun 2003 ~ Sep 2004 Subproject Leader/BioMedicine Division
Development Center for Biotechnology, Taiwan
Jan 2003 ~ Jun 2003 Research Scientist/BioMedicine Division
Development Center for Biotechnology, Taiwan
Mar 2002 ~ Dec 2002 Post-Doctoral Fellow/Dr. Tse-Wen Chang’s Lab
Department of Life Science, Tsing-Hua University, Taiwan
SUMMARY of PROF. JIM J.-C. SHEU’S RESEARCH
Dr. Sheu’s research interest focuses on identification and characterization of tumor-associated genes by genome-wide studies and gene function characterizations. In the past years, Dr. Sheu has defined Rsf-1, also known as HBXAP, a potent cancer-driving gene during cancer development and progression. The crosstalk between Rsf-1 and SNF2H is the key for promoting oncogenic signaling in cancer cells, resulting in gross tumor growth and drug resistance. These findings enable Rsf-1 as an attractive target for new therapy development. On the other hand, Rsf-1 overexpression serves as a selecting barrier to allow outgrowth of cell clones with genetic defects in self-surveillance that subsequently eases cancer cells to accumulate more genetic alterations. With fruitful achievements in the Rsf-1 study, Dr. Sheu won the Wu-Da-You Memorial Award, a national academic research award for outstanding young scientists in Taiwan, in 2014.
In addition to the Rsf-1 project, Dr. Sheu also study head and neck cancer including oral squamous cell carcinoma (OSCC) and nasopharyngeal carcinoma (NPC) using comparative analyses between genomic and transcriptome maps. Dr. Sheu has successfully validated EGFR activation, either through gene amplification/overexpression or activation of downstream effectors, is the most frequent genetic event in OSCC. Also, deletion of 3p12.3-p14.2 and amplification of 3q26.2-q26.32 were found to serve as genomic markers for advanced NPC, which might be the footprints of frequent Epstein-Barr virus reactivation. On the other hand, LRIG1, a negative regulator for EGFR signaling, functions as a tumor suppressor in head and neck cancer through down-regulation of EGFR ligands and extracellular remodeling activity. Using similar approach, Dr. Sheu also identified TLN1 amplification/overexpression responsible for OSCC migration and invasion, thus could be utilized as a good therapeutic target. Furthermore, Rsf-1 and haptoglobin were found as valuable biomarkers for predicting clinical outcome and tumor recurrence.
Currently, Dr. Sheu is studying novel keratin fusions in human squamous cell carcinomas and their roles in tumor microenvironment and cancer stem cell development. In addition, ribosome biogenesis has been found as one of cancer drivers to promote malignant transition and tumor development.
AWARDS/HONORS
2015 Chair of Life Sciences, Frontiers of Science Symposium Taiwan
France-Taiwan Frontiers of Science (FT-FoS) sponsored by Ministry of Science and Technology (MOST), Taiwan
2014-2017 Outstanding Young Investigator Award sponsored by National Sun Yatsen University
2014 IBC Outstanding Scientific Achievement/International Biographical Centre, Cambridge
2014 National Science Council Academic Research Award-Wu-Da-You Memorial Award
2013 2013 Marquis Who’s Who in the world
2010-2014 Outstanding Research Award sponsored by National Science Council
2009 Medical Young Investigator Award sponsored by Prof. Chen-Yuan Lee Foundation
2008-2014 Outstanding Research Awards sponsored by China Medical University
2008 Best innovation in basic research and teaching
Summer student program sponsored by National Science Council
2005 Basic Science 1st Place Winners of Fellow Research Day
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
2003 Government-financed student to study abroad (USA)
sponsored by Ministry of Education/TAIWAN
Invited reviewer/Editor
A. Editorial Board Member
1. World Journal of Clinical Cases
2. American Journal of Human Pathology
3. Journal of Alternative, Complementary & Integrative Medicine
B. Reviewer for Journal Papers
1. International Journal of Molecular Sciences
2. Journal of Zhejiang University-SCIENCE B
3. African Journal of Pharmacy and Pharmacology
4. Tumor Biology
5. Carcinogenesis
6. International Journal of Traditional and Complementary Medicine
7. Journal of Oral Pathology and Medicine
8. Cancer Letters
9. Yonsei Medical Journal
10. Evidence-Based Complementary and Alternative Medicine
11. The American Journal of Chinese Medicine
C. Reviewer for Research Projects
1. 2010 Project Reviewer, Mainland Affairs Council (MAC), Taiwan
2. 2012 International Project Reviewer, the Medical Research Council (MRC), South African
3. 2012-2013 Project Reviewer, National Science Council (NSC), Taiwan
4. 2015 International Project Reviewer, Italian Ministry of Health, Italy
D. Reviewer for Administrative Services
1. Evaluation Committee Member, Department of Higher Education, Ministry of Education (MOE), Taiwan
RESEARCH PROJECTS (Ministry of Science and Technology/TAIWAN)
Principal Investigator
1. Chromatin remodeling factor Rsf-1 triggers genome instability during cancer development (NSC-98-2320-B-039-033-MY3; 2009.08 ~ 2012.07; TOTAL=4,050,000 NTD)
2. Novel keratin fusions in squamous cell carcinoma development (NSC-101-2320-B-039-006-; 2012.08 ~ 2013.07; TOTAL=1,050,000 NTD)
3. Novel keratin fusions in squamous cell carcinoma development (2) (NSC-102-2628 -B-039-001-MY3; 2013.08 ~ 2016.07; TOTAL=3,900,000 NTD)
4. The biological functions of nuclear VCP interactome in oral squamous cell carcinoma development (MOST 103-2314-B-039 -009 -MY3; 2013.08 ~ 2016.07; TOTAL = 3,900,000 NTD)
Co-Investigator
5. Signal transduction of the genetic variant of human growth hormone receptor (codon 440 G/T) (NSC-96-2314-B-039-006-MY3; 2007.08 ~ 2010.07; TOTAL=3,530,000 NTD)
6. Mechanism study of enterovirus-71 infection using genomic and proteomic approaches: the anti-viral effects of kaempferol and bioflavonoids (NSC-97-2320-B-039-023-MY3; 2008.08 ~ 2011.07; TOTAL=3,060,000 NTD)
7. The inhibitory effects of type-1 interferon on cell growth: the functional roles of STAT6 (NSC-98-2320-B-039-008-MY3; 2009.08 ~ 2012.07; TOTAL=3,660,000 NTD)
8. Bioinformatics tools for fusion protein interaction and epigenetic-regulated microRNA pathway in cancer biology (NSC-102-2221-E-468-024-; 2013.08 ~ 2014.07; TOTAL=806,000 NTD)
INVITED LECTURES (at international conferences)
1. Sheu JJ* (2008.12.06-2008.12.07)
Genome analysis of oral cancer.
2008 Asia-Pacific Congress on Oral Cavity Cancer in conjunction with 12th Annual Meeting of Taiwan Cooperative Oncology Group
2. Sheu JJ* and Chia-Huei Lee (2010.07.01-2010.07.04)
The role of LRIG1 in nasopharyngeal carcinoma.
2010 1st Midnight Sun Symposium LRIG Proteins and the Regulation of Growth Factor Signaling
3. Sheu JJ*, Wang TL, Shih IeM (2011.08.06-2011.08.08)
Chromatin remodeling and cancer development: a story about Rsf-1/HBXAP.
2011 BIT's 1st Annual World Congress of Molecular & Cell Biology
4. Sheu JJC, Cheng JSC, Chao SJC, Tsai FJ (2012.05.14-2012.05.16)
Nuclear VCP acts as a tumor promoting factor for oral squamous cell carcinoma. Global Academic Programs 2012 Conference/MD Anderson Medical University.
5. Sheu JJC, Cheng JSC, Chao SJC, Tsai FJ (2012.05.18-2012.05.19)
Recurrent keratin fusion in oral squamous cell carcinoma.
2012 International Symposium on Clinical and Translational Cancer Research.
6. Lee CH and Sheu JJ* (2012.05.24-2012.05.27)
LRIG1 modulates aggressiveness of head or neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling.
2nd Midnight Sun Symposium LRIG Proteins and the Regulation of Growth Factor Signaling.
7. Sheu JJ (2013.10.31-2013.11.02) Tianjin, China
RSF-1, a chromatin remodeling protein, interacts with cyclin E1 and promotes tumor development
The 22nd Asia Pacific Cancer Conference
8. Sheu JJ*, Choi JH, Guan B, Wang TL, Shih IeM (2014.04.25-2014.04.28) Dalian, China
RSF-1, a chromatin remodeling protein, interacts with cyclin E1 and promotes tumor development
BIT’s 4th Annual World Congress of Molecular & Cell Biology (Chair of the section)
9. Sheu JJ (2014.09.11-2014.09.14) Jinan, China
RSF chromatin remodeling complex induces genome instability and drug resistance via transcriptional activation of PARG
The 8th Chinese Conference on Oncology &
The 13th Cross-Strait Academic Conference on Oncology
10. Sheu JJ (2015.03.07-2015.03.08) Kaohsiung, Taiwan
New treatment for cancer: immunotherapy & beyond
France-Taiwan Frontiers of Science (FT-FoS) Symposium Taiwan
Publication LIST
A. Journal Articles
Cancer Research
1. Sheu JC, Hsu CP, Yang CC, Yang SD. (1998) Acute inductive effects on oncogenic proline-directed protein kinase (PDPK) FA/GSK-3a in NIH 3T3 cells by ethanol and cadmium. Proc. Natl. Sci. Counc. Repub. China B. 22:68-75.
2. Yang CC, Hsu CP, Sheu JC, Mai XY, Yang SD. (1998) Differential tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase (PDPK) FA/GSK-3a in well and poorly differentiated human prostate carcinoma cells. J. Protein Chem. 17:329-35.
3. Huang J, Sheu JJ, Wu SC, Chang TW. (2002) Down regulation of B cells by immunization with a fusion protein of a self CD20 peptide and a foreign IgG.Fc fragment. Immunol. Lett. 81:49-58.
4. Sheu JJC, Huang J, Chang TW. (2002) Inducing specific reactivity against B cells in mice by immunizing with an Fc fusion protein containing self-Igβ. Cancer Immunol. Immunother. 51:145-151.
5. Sheu JJC, Huang J, Cheng T, Lim C, Chang TW. (2003) Comparative effects of human Igαand Igβ in inducing auto-/cross-reactive antibodies against B cells in mice. J. Immunol. 170:1158-66.
6. Shih IeM, Sheu JJ, Santillan A, Yu CH, Yen MJ, Hwang T, Nakayama K, Bristow RE, Vang R, Parmigiani G, Kurman RJ, Trope CG, Davidson B, Wang TL. (2005) Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma. Proc. Natl. Acad. Sci. USA. 102:14004-9.
7. Mao TL, Hsu CY, Yen MJ, Gilks B, Sheu JJ, Gabrielson E, Vang R, Cope L, Kurman RJ, Wang TL, Shih IeM. (2006) Expression of Rsf-1, a chromatin-remodeling gene, in ovarian and breast carcinoma. Hum Pathol. 37:1169-75.
8. Nakayama K, Nakayama N, Davidson B, Sheu JJ, Jinawath N, Salani R, Kurman RJ, Morin P, Santillan A, Bristow RE, Shih IeM, Wang TL. (2006) A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival. Proc. Natl. Acad. Sci. USA. 103:18739-44.
9. Sheu JJ-C, Shih I-M. (2007) Clinical and biological significance of HLA-G expression in ovarian cancer. Semin Cancer Biol. 17:436-43.
10. Wan L, Lin CW, Lin YJ, Sheu JJ, Chen BH, Liao CC, Tsai Y, Lin WY, Lai CH, Tsai FJ. (2008) Type I IFN induced IL1-Ra expression in hepatocytes is mediated by activating STAT6 through the formation of STAT2 : STAT6 heterodimer. J Cell Mol Med. 12; 876-88.
11. Sheu JJ, Choi JH, Yýldýz I, Tsai FJ, Shaul Y, Wang TL, Shih IM. (2008) The roles of human sucrose nonfermenting protein 2 homologue in the tumor-promoting functions of Rsf-1. Cancer Res. 68; 4050-7.
12. Lee CH, Fang CY, Sheu JJ, Chang Y, Takada K, Chen JY (2008) Amplicons on chromosome 3 contain oncogenes induced by recurrent TPA / SB exposure and Epstein-Barr virus reactivation in a nasopharyngeal carcinoma cell line. Cancer Genetics and Cytogenetics. 185: 1-10.
13. Lin YJ, Hou YC, Lin CH, Hsu YA, Sheu JJ, Lai CH, Chen BH, Lee Chao PD, Wan L, Tsai FJ. (2009) Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem Biophys Res Commun. 378: 683-8.
14. Choi JH, Sheu JJ, Guan B, Jinawath N, Markowski P, Wang TL, Shih IM. (2009) Functional analysis of 11q13.5 amplicon identifies Rsf-1 (HBXAP) as a gene involved in paclitaxel resistance in ovarian cancer. Cancer Res. 69:1407-15.
15. Sheu JJ, Hua CH, Wan L, Lin YJ, Lai MT, Tseng HC, Jinawath N, Tsai MH, Chang NW, Lin CF, Lin CC, Hsieh LJ, Wang TL, Shih IeM, Tsai FJ. (2009) Functional genomic analysis identified EGFR activation as the most common genetic event in oral squamous cell carcinoma. Cancer Res. 69:2568-76.
16. Sheu JJ, Lee CH, Ko JY, Tsao G, Wu CC, Fang CY, Tsai FJ, Hua CH, Chen CL, Chen JY. (2009) Chromosome 3p12.3-p14.2 and 3q26.2-q26.32 are genomic markers for prognosis of advanced nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 18:2709-16.
17. Sun L, Kong B, Sheng X, Sheu JJ, Shih IeM (2010) Dendritic cells transduced with Rsf-1/HBXAP gene generate specific cytotoxic T lymphocytes against ovarian cancer in vitro. Biochem Biophys Res Commun. 394:633-8.
18. Sheu J, Shih IM (2010) HLA-G and immune evasion in cancer cells. J Formos Med Assoc 109:248-57
19. Lai CH, Chang NW, Lin CF, Lin CD, Lin YJ, Wan L, Sheu JJ, Chen SY, Huang YP, Sing YT, Tao TW, Lai CK, Tsai MH, Chan HL, Jou YJ, Lin CW (2010) Proteomics-based identification of haptoglobin as a novel plasma biomarker in oral squamous cell carcinoma. Clin Chim Acta. 411:984-91.
20. Sheu JJ, Guan B, Choi JH, Lin A, Lee CH, Hsiao YT, Wang TL, Tsai FJ, Shih IM (2010) Rsf-1, a chromatin remodeling protein, induces DNA damage and promotes genomic instability. J Biol Chem 285:38260-9. (corresponding author)
21. Chang CYY, Chang HW, Chen CM, Lin CY, Chen CP, Lai CH, Lin WY, Liu HP, Sheu JJ, Tsai FJ (2011) MUC4 gene polymorphisms associate with endometriosis development and infertility. BMC Med 9:19. (corresponding author)
22. Fang FM, Li CF, Huang HY, Lai MT, Chen CM, Chiu IW, Wang TL Tsai FJ, Shih IM, Sheu JJ (2011) Overexpression of a chromatin remodeling factor, Rsf-1/HBXAP, correlates with aggressive oral squamous cell carcinoma. Am J Pathol 178:2407-15. (corresponding author)
23. Lai MT, Hua CH, Tsai MH, Wan L, Lin YJ, Chen CM, Chiu IW, Chan C, Tsai FJ, Sheu JJ (2011) Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis. J Pathol 224:367-76. (corresponding author)
24. Hsu YA, Lin HJ, Sheu JJ, Shieh FK, Chen SY, Lai CH, Tsai FJ, Wan L, Chen BH (2011) A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells. DNA Cell Biol 30:671-9.
25. Lai CH, Wang HJ, Chang YC, Hsieh WC, Lin HJ, Tang CH, Sheu JJ, Lin CJ, Yang MS, Tseng SF, Wang WC (2011) Helicobacter pylori CagA-mediated IL-8 induction in gastric epithelial cells is cholesterol-dependent and requires the C-terminal tyrosine phosphorylation-containing domain. FEMS Microbiol Lett 323:155-63.
26. Liu PY, Sheu JJ, Lin PC, Lin CT, Liu YJ, Ho LI, Chang LF, Wu WC, Chen SR, Chen J, Harn YC, Lin SZ, Tsai CH, Chiou TW, Harn HJ (2012) Expression of Nur77 induced by an n-butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma. Invest New Drugs 30:79-89.
27. Sheu JJ, Guan B, Tsai FJ, Hsiao EY, Chen CM, Wang TL, Shih IM (2012) Mutant BRAF induces DNA strand breaks, activates DNA damage response pathway and upregulates glucose transporter-1 in nontransformed epithelial cells. Am J Pathol 180:1179-88. (corresponding author)
28. You HL, Weng SW, Li SH, Wei YC, Sheu JJ, Chen CM, Huang WT (2012) Copy number aberrations in combined hepatocellular carcinoma and cholangiocarcinoma. Exp Mol Pathol. 92:281-6.
29. Liang PI, Wu LC, Sheu JJ, Wu TF, Shen KH, Wang YH, Wu WR, Shiue YL, Huang HY, Hsu HP, Chen YH, Chen LT, Li CF, Liao AC (2012) Rsf-1/HBXAP overexpression is independent of gene amplification and is associated with poor outcome in patients with urinary bladder urothelial carcinoma. J Clin Pathol. 65:802-7.
30. Liu PY, Lin SZ, Sheu JJ, Lin CT, Lin PC, Chou YW, Huang MH, Chiou TW, Harn HJ (2013) Regulation of androgen receptor expression by Z-isochaihulactone mediated by the JNK signaling pathway and might be related to cytotoxicity in prostate cancer. Prostate 73:531-41.
31. Sheu JJC, Choi JH, Guan B, Tsai FJ, Hua CH, Lai MT, Wang TL, Shih IM (2013) Rsf-1, a chromatin remodeling protein, interacts with cyclin E1 and promotes tumor development. J Pathol. 229:559-68. (corresponding author)
32. Chang CYY, Chen Y, Lai MT, Chang HW, Cheng J, Chan C, Chen CM, Lee SC, Lin YJ, Wan L, Tsai PW, Yang SH, Sheu JJC, Tsai FJ (2013) BMPR1B up-regulation via a miRNA binding site variation defines endometriosis susceptibility and CA125 levels. Plos One 8: e80630. (corresponding author)
33. Sheu JJC, Lee CC, Hua CH, Li CI, Lai MT, Lee SC, Cheng J, Chen CM, Chan C, Chao SCC, Chen JY, Chang JY, Lee CH (2014) LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling. Oncogene 33:1375-84. (corresponding author)
34. Wang YH, Wu WJ, Wang WJ, Huang HY, Li WM, Yeh BW, Wu TF, Shiue YL, Sheu JJ, Wang JM, Li CF (2015) CEBPD amplification and overexpression in urothelial carcinoma: a driver of tumor metastasis indicating adverse prognosis. Oncotarget 6:31069-84.
Genetic Diseases and Others
1. Lin YJ, Wan L, Sheu JJC, Huang CM, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH Tsai FJ. (2008) A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients. Lupus. 17: 124-7.
2. Lin YJ, Wan L, Sheu JJ, Huang CM, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin WY, Liu HP, Lin TH, Huang YM, Tsai FJ (2008) G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan. Clin Immunol. 129:36-9.
3. Chang HL, Tang CH, Hsu YM, Wan L, Chang YF, Lin CT, Tseng YR, Lin YJ, Sheu JJ, Lin CW, Chang YC, Ho MW, Lin CD, Ho CM, Lai CH. (2009) Nosocomial Outbreak of Infection With Multidrug-Resistant Acinetobacter baumannii in a Medical Center in Taiwan. Infect Control Hosp Epidemiol. 30: 34-8.
4. Wan L, Lin YJ, Sheu JJ, Huang CM, Tsai Y, Tsai CH, Wong W, Tsai FJ. (2009) Analysis of ERCC2/XPD functional polymorphisms in systemic lupus erythematosus. Int. J. Immunogenetics. 36:33-7. (Co-first author)
5. Lin YJ, Wan L, Wu JY, Sheu JJ, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin TH, Lin JG, Hsueh KC, Huang YM, Chang JS, Tsai FJ. (2009) HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. Arth & Rheum. 60:604-10.
6. Wan L, Kung YJ, Lin YJ, Liao CC, Sheu JJ, Tsai Y, Lai HC, Peng CY, Tsai FJ. (2009) Th1 and Th2 cytokines are elevated in HCV-infected SVR(-) patients treated with interferon-alpha. Biochem Biophys Res Commun. 379:855-60.
7. Chen SY, Wan L, Huang YC, Sheu JJ, Lan YC, Lai CH, Lin CW, Chang JS, Tsai Y, Liu SP, Lin YJ, Tsai FJ. (2009) Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease. J Clin Lab Anal. 23:71-6.
8. Lin YJ, Chen RH, Wan L, Sheu JC, Huang CM, Lin CW, Chen SY, Lai CH, Lan YC, Hsueh KC, Tsai CH, Lin TH, Huang YM, Chao K, Chen DY, Tsai FJ. (2009) Association of TNF-alpha gene polymorphisms with systemic lupus erythematosus in Taiwanese patients. Lupus. 18:974-9.
9. Liu HP, Lin YJ, Lin WY, Wan L, Sheu JJ, Lin HJ, Tsai Y, Tsai CH, Tsai FJ (2009) A novel genetic variant of BMP2K contributes to high myopia. J Clin Lab Anal. 23:362-7.
10. Lin YJ, Wan L, Huang CM, Chen SY, Huang YC, Lai CH, Lin WY, Liu HP, Wu YS, Chen CM, Tsai YH, Tsai CH, Sheu JJ, Tsai FJ. (2009) Polymorphisms in the DNA repair gene XRCC1 and associations with systemic lupus erythematosus risk in the Taiwanese Han Chinese population. Lupus 18:1246-51. (Co-corresponding author)
11. Lin HJ, Kung YJ, Lin YJ, Sheu JJ, Chen BH, Lan YC, Lai CH, Hsu YA, Wan L, Tsai FJ (2010) Association of the Lumican gene functional 3' UTR polymorphism with high myopia. Invest Ophthalmol Vis Sci. 51:96-102.
12. Lin YJ, Wan L, Huang CM, Sheu JJ, Chen SY, Lin TH, Chen DY, Hsueh KC, Lai CC, Tsai FJ (2010) IL-10 and TNF-alpha promoter polymorphisms in susceptibility to systemic lupus erythematosus in Taiwan. Clin Exp Rheumatol. 28:318-24.
13. Sheu JJ, Lin YJ, Chang JS, Wan L, Chen SY, Huang YC, Chan C, Chiu IW, Tsai FJ (2010) Association of COL11A2 polymorphism with susceptibility to Kawasaki disease and development of coronary artery lesions. Int J Immunogenet 37:487-92.
14. Huang YC, Lin YJ, Chang JS, Chen SY, Wan L, Sheu JJ, Lai CH, Lin CW, Liu SP, Chen CP, Tsai FJ (2010) Single nucleotide polymorphism rs2229634 in the ITPR3 gene is associated with the risk of developing coronary artery aneurysm in children with Kawasaki disease. Int J Immunogenet. 37:439-43.
15. Chen SY, Wan L, Huang CM, Huang YC, Sheu JJ, Lin YJ, Liu SP, Lan YC, Lai CH, Lin CW, Tsai CH, Tsai FJ (2010) Genetic polymorphisms of the DNA repair gene MPG may be associated with susceptibility to rheumatoid arthritis. J Appl Genet. 51:519-21.
16. Chang PC, Chen Y, Lai MT, Chang HY, Huang CM, Liu HP, Lin WY, Lai CH, Sheu JJ, Tsai FJ (2011) Association Analysis of Polymorphisms in Lumican Gene and Systemic Lupus Erythematosus in a Taiwan Chinese Han Population. J Rheumatol 38:2376-81. (corresponding author)
17. Tsai FJ, Lin CW, Lai CC, Lan YC, Lai CH, Hung CH, Hsueh KC, Lin TH, Chang HC, Wan L, Sheu JJC, Lin YJ (2011) Kaempferol inhibits enterovirus 71 replication and internal ribosome entry site (IRES) activity through FUBP and HNRP proteins. Food Chem 128:312–22.
18. Chen SY, Wan L, Huang CM, Huang YC, Sheu JJ, Lin YJ, Liu SP, Lan YC, Lai CH, Lin CW, Tsai CH, Tsai FJ (2012) Association of the C-285T and A5954G polymorphisms in the DNA repair gene OGG1 with the susceptibility of rheumatoid arthritis. Rheumatol Int 32:1165-9.
19. Chang CY, Chen Y, Lin WC, Chen CM, Chen CP, Lee SC, Sheu JJ, Tsai FJ (2012) MUC2 polymorphisms are associated with endometriosis development and infertility: a case-control study. BMC Med Genet 13:15. (corresponding author)
20. Lin WY, Wu BT, Lee CC, Sheu JJ, Liu SH, Wang WF, Tsai CH, Liu HP, Tsai FJ (2012) Association analysis of dopaminergic gene variants (Comt, Drd4 And Dat1) with Alzheimer s disease. J Biol Regul Homeost Agents 26:401-10.
21. Lin WY, Lee CC, Liu HP, Chou IC, Sheu JJ, Wan L, Lin YJ, Tsai Y, Tsai FJ (2012) Association of genetic variations in X-ray repair cross-complementing group 1 and Tourette syndrome. J Clin Lab Anal 26:321-4.
22. Lin WY, Liu HP, Chang JS, Lin YJ, Wan L, Chen SY, Huang YC, Lai CH, Chen CM, Hsiao YT, Sheu JJ, Tsai FJ (2013) Genetic variations within the PSORS1 region affect Kawasaki disease development and coronary artery aneurysm formation. Biomed 3:73-81. (corresponding author)
23. Yang CW, Chang CY, Lai MT, Chang HW, Lu CC, Chen Y, Chen CM, Lee SC, Tsai PW, Yang SH, Lin CH, Sheu JJ, Tsai FJ (2015) Genetic variations of MUC17 are associated with endometriosis development and related infertility. BMC Med Genet 16:60. (corresponding author)
B. Conference Report
1. Sheu JJC, Chang TW. (2000)
Induction of specific autoantibodies against CD79a in mice by immunizing with human CD79a fused with IgG1.Fc.
FASEB J. 14(6):A1123
2. Leslie YY, Sheu JJC, Chang TW. (2000)
Regulation of B cell activity by inducing specific autoimmune response against CD79b.
FASEB J. 14(6):A1123.
3. Sheu JJ, Yu T, Huang ML, Tsai WL. (2002)
Suppressing tumor progression and inducing cell differentiation on prostate cancer cells by human psychosomatic power.
Experimental Biology 2002. 257.6:31.
4. Sheu JJ, Chen MY, Chang TW. (2002)
Preparation of recombinant human anti-enterovirus 71 neutralizing antibodies for clinical applications.
Experimental Biology 2002. 240.9:87.
5. Sheu JJ, Tsai CC, Hsu CL, Chang TW. (2004)
Preparation of epitope-specific monoclonal antibodies to neutralize SARS-CoV
Experimental Biology 2004. 283:7:21.
6. Sheu JJ, Santillan A, Yu CH, Yen MJ, Hwang T, Nakayama K, Bristow RE, Vang R, Parmigiani G, Kurman RJ, Trope CG, Davidson B, Shih I, Wang TL. (2005)
Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma.
Johns Hopkins Fellow’s Day 2005
7. Chiu YW, Lai MT, Li ZY, Wan L, Tsai FJ, Sheu JJC*. (2007)
Oncogenic activity of Rsf-1/HBXAP depends on p53 mutation status
The 1st International Cancer Symposium 2007.
8. Chan C, Shih TL, Tsai FJ, Wan L, Lin YJ, Wang TL, Shih IM, Sheu JJC*. (2007)
Down regulation of chromatin remodeling activity triggers cell death in RSF-1/HBXAP amplified cancer cells.
The 1st International Cancer Symposium 2007.
9. Chiu IW, Chiou YW, Wan L, Lin YJ, Lai CH, Chen SY, Huang CM, Tsai CH, Tsai FJ, Sheu JJC* (2008.10.04-2008.10.05)
Analysis of ERCC2/XPD functional polymorphisms in systemic lupus erythematosus.
2008 Taiwan Human Genetic Society Autumn Symposium: page 40. (Oral presentation)
10. Chan C, HsiaoYT, Wan L, Lin YJ, Lai CH, Chen SY, Huang CM, Tsai CH, Tsai FJ, Sheu JJC* (2008.10.04-2008.10.05)
Association analysis of polymorphisms in lumican and systemic lupus erythematosus in Han Taiwan Chinese population.
2008 Taiwan Human Genetic Society Autumn Symposium: page 49. (Oral presentation)
11. Wu YS, Chen CM, Wan L, Lin YJ, Lai CH, Huang CM, Tsai YH, Tsai CH, Tsai FJ, Sheu JJC* (2008.10.04-2008.10.05)
Association between polymorphisms in the DNA repair gene XRCC1 and systemic lupus erythematosus in Han Taiwan Chinese population.
2008 Taiwan Human Genetic Society Autumn Symposium: page 57. (Oral presentation)
12. Sheu JJ (2008.12.06-2008.12.07)
Genome analysis of oral cancer
2008 Asia-Pacific Congress on Oral Cavity Cancer in conjunction with 12th Annual Meeting of Taiwan Cooperative Oncology Group: page 7 (Oral presentation)
13. Chiu IW, Chen CM, Hua CH, Wan L, Lin YJ, Lai MT, Tseng HC, Tsai MH, Tsai FJ, Wang TL, Shih IM, Sheu JJC (2009.4.18-2009.4.22)
Functional genomic analysis identified EGFR activation as the most common genetic event in oral squamous cell carcinoma
2009 100th Annual Meeting of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research (2009) 50: 626.
14. Sheu JJC, Chan C, Chen CM, Hsiao E, Hua CH, Wan L, Lin YJ, Lai MT, Tseng HC, Tsai MH, Tsai FJ (2009.4.18-2009.4.22)
Activation of oncogenes at 3q and 8q amplicons by somatic mutations in oral squamous cell carcinoma
2009 100th Annual Meeting of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research (2009) 50: 339.
15. Sheu JJC, Lai MT, Tseng HC, Lin YJ, Wan L, Hua CH, Tsai MH, Chiu IW, Chang NW, Lin CF, Chen CM, Lee MM, Tsai FJ (2010.4.17-2010.4.21)
Overexpression of talin 1 (TLN1) in invasive oral squamous cell carcinoma (OSCC)
2010 101st Annual Meeting of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research (2010) 51: 1226.
16. Chiu IW, Li CF, Lai CC, Lai MT, Chen CM, Lin YJ, Wan L, Tseng HC, Hua CH, Tsai MH, Hsu WY, Tsai FJ, Sheu JJC (2010.4.17-2010.4.21)
Oncogenic roles of nuclear VCP in oral cancer development
2010 101st Annual Meeting of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research (2010) 51: 754.
17. Sheu JJ and Chia-Huei Lee (2010.7.1-2010.7.4) (Oral presentation)
The role of LRIG1 in nasopharyngeal carcinoma.
2010 1st Midnight Sun Symposium LRIG Proteins and the Regulation of Growth Factor Signaling
18. Sheu JJC, Li CF, Huang HY, Lai MT, Chen CM, Tsai FJ, Shih IM (2011.4.2-2011.4.6)
Overexpression of a chromatin remodeling factor, Rsf-1/HBXAP, correlates with aggressive oral squamous cell carcinoma
2011 102nd Annual Meeting of the American Association for Cancer Research
Proceedings of the American Association for Cancer Research (2011) 52: 960-961.
19. Sheu JJ*, Wang TL, Shih IeM (2011.8.6-2-2011.8.8) (Oral presentation)
Chromatin remodeling and cancer development: a story about Rsf-1/HBXAP
2011 BIT's 1st Annual World Congress of Molecular & Cell Biology
20. Lin ZJ, Lee SC, Sheu JJC* (2012.03.17-2012.03.18)
YWHAZ amplification contributes to chemo-resistance and recurrence of bladder cancer
2012 The 27th Joint Annual Conference of Biomedical Science
21. Sheu JJC, Cheng JSC, Chao SJC, Tsai FJ (2012.05.14-2012.05.16) (Oral presentation)
Nuclear VCP acts as a tumor promoting factor for oral squamous cell carcinoma.
Global Academic Programs 2012 Conference/MD Anderson Medical University.
22. Sheu JJC, Cheng JSC, Chao SJC, Tsai FJ (2012.05.18-2012.05.19) (Oral presentation)
Recurrent keratin fusion in oral squamous cell carcinoma.
Title changed to Chromatin remodeling and cancer development: the story of Rsf-1/HBXAP
2012 International Symposium on Clinical and Translational Cancer Research.
23. Lee CH and Sheu JJ* (2012.05.24-2012.05.27) (Oral presentation)
LRIG1 modulates aggressiveness of head or neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling.
2nd Midnight Sun Symposium LRIG Proteins and the Regulation of Growth Factor Signaling.
24. Korla PK, Lee SC, Sheu J, Cheng J, Ng KL* (2013.02.24-2013.02.25)
In silico study of non-coding, coding transcription region and domain interaction for chromosomal translocation sequences.
3rd International Conference on Bioscience and Bioinformatics, Switzerland, Dec. 29 -31, 2012.
25. Cheng J, Lai MT, Chen CM, Chan C, Lee SC, Ng KL, Sheu JJ* (2013.03.23-2013.03.24)
Discovery of oral squamous cell carcinoma-associated oncogenes using genomewide technologies.
2013 The 28th Joint Annual Conference of Biomedical Science
26. Cheng J, Lai MT, Lee SC, Chao SCC, Chen CM, Sheu JJC* (2013.04.06-2013.04.10)
Identification of novel keratin fusion in squamous cell carcinomas.
2013 104nd Annual Meeting of the American Association for Cancer Research
27. Sheu JJ (2013.10.31-2013.11.02) Tianjin, China (Oral presentation)
RSF-1, a chromatin remodeling protein, interacts with cyclin E1 and promotes tumor development
The 22nd Asia Pacific Cancer Conference
28. Sheu JJ*, Choi JH, Guan B, Wang TL, Shih IeM (2014.04.25-2014.04.28) Dalian, China (Oral presentation)
RSF-1, a chromatin remodeling protein, interacts with cyclin E1 and promotes tumor development
BIT’s 4th Annual World Congress of Molecular & Cell Biology (Chair of the section)
29. Sheu JJ (2014.09.11-2014.09.14) Jinan, China (Oral presentation)
RSF chromatin remodeling complex induces genome instability and drug resistance via transcriptional activation of PARG
The 8th Chinese Conference on Oncology &
The 13th Cross-Strait Academic Conference on Oncology
30. Sheu JJ, Lai MT, Lee SC, Chen CM, Cheng J, Chao SCC, Tsai FJ (2015.04.18-2015.04.22) Philadelphia, USA
Detection of keratin fusions in oral squamous cell carcinoma
2015 106nd Annual Meeting of the American Association for Cancer Research
C. Patent
1. Chang TW, Sheu JJC, Huang JSW, Wu SCS, Chen LYY.
Composition and methods for induction of active autoimmunity.
U.S. Patent Application: 20020102232.
2. Chang TW, Sheu JJC, Lo LH, Chen NY, Lin YS.
Recombinant enterovirus 71 neutralizing antibodies and applications thereof
Hong Kong Patent Application: 1099312.
Taiwan (R.O.C.) Patent Number: I296930 issued on May 21, 2008.
U.S. Patent Number: 7,482,006 issued on Jan 27, 2009.
China Patent Number: 100513424C issued on July 15, 2009.
3. Sheu JJC, Chang YL, Chen TS, Liou SY
Composition of Chinese medicine recipes for cancer therapy
Taiwan (R.O.C.) Patent Application: 201119663.
4. Sheu JJC, Tsai FJ, Cheng J, Chao SJC
Method for in vitro detecting keratin gene fusion of squamous-cell cancer
活體外檢測鱗狀細胞癌的方法
Taiwan (R.O.C.) Patent Number: I468519 issued on Jan 11/2015.
U.S. Patent Application: 2013785829.
D. Others
1. 許晉銓 (2009) 鱗狀細胞口腔癌之功能性基因體分析. TCOG (Taiwan Cooperative Oncology Group) News 2009.10: 2-5.
2. Korla PK, Lee SC, Sheu J, Cheng J, Ng KL (2012) In silico study of non-coding, coding transcription region and domain interaction for chromosomal translocation sequences. Adv Env Comput Chem and Biosci 290-5.
