huang
Huang, Hurng-Wern PhD
Assistant Professor, Institute of Biomedical Sciences, National Sun Yat-sen University
Ph: +886-7-5252000 ext. 5814
Email: sting@mail.nsysu.edu.tw
Address: 70 Lienhai Rd. Kaohsiung, 80424, Taiwan
Research interests:Cancer biology, Drug mechanisms, Signal transduction, Autophagy
Education:
1982-1986: National Tsing Hua University, HsingChu, Taiwan, R.O.C.
B.S. Degree in Chemical Engineering.
1986-1988:National Tsing Hua University, HsingChu, Taiwan, R.O.C.
M.S. Degree in Molecular Biology.
1988-1993: National Tsing Hua University, HsingChu, Taiwan, R.O.C.
Ph. D. Degree in Life Science.
Professional Experiences:
|
1999-present |
Assistant Professor |
Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan |
Research fields:
1. Differential expressed biomarker in caners, including oral cancer, colon cancer.
2. Protein high throughput analysis with 2D-electrophoresis and MS.
3. Drugs/compounds from natural products analysis of anti-tumor, autophagy, apoptosis mechanisms.
Publication lists:
1. Chou HL, Fong Y, Wei CK, Tsai EM, Chen JY, Chang WT, Wu CY, Huang HW, Chiu CC. A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling. Arch Immunol Ther Exp (Warsz). 2016 Sep 27. [Epub ahead of print]
2. Chen CY, Yen CY, Wang HR, Yang HP, Tang JY, Huang HW, Hsu SH, Chang HW. Tenuifolide B from Cinnamomum tenuifolium Stem Selectively Inhibits Proliferation of Oral Cancer Cells via Apoptosis, ROS Generation, Mitochondrial Depolarization, and DNA Damage. Toxins (Basel). 2016 Nov 5;8(11). pii: E319.
3. Chang HS, Tang JY, Yen CY, Huang HW, Wu CY, Chung YA, Wang HR, Chen IS, Huang MY, Chang HW. Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage. BMC Complement Altern Med. 2016 Mar, 16:94.
4. Chang HW, Tang JY, Yen CY, Chang HS, Huang HW, Chung YA, Chen IS, Huang MY. Synergistic anti-oral cancer effects of UVC and methanolic extracts of Cryptocarya concinna roots via apoptosis, oxidative stress and DNA damage. Int J Radiat Biol. 2016 May, 92(5):263-72.
5. Yen CY, Huang HW, Shu CW, Hou MF, Yuan SS, Wang HR, Chang YT, Farooqi AA, Tang JY, Chang HW. DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers. Cancer Lett. 2016 Apr 10;373(2):185-92.
6. Farooqi AA, Li RN, Huang HW, Ismail M, Yuan SS, Wang HM, Liu JR, Tang JY, Chang HW.Natural Products Mediated Regulation of Oxidative Stress and DNA Damage in Ultraviolet Exposed Skin Cells.Curr Pharm Biotechnol. 2015;16(12):1078-84.
7. Yen CY, Hou MF, Yang ZW, Tang JY, Li KT, Huang HW, Huang YH, Lee SY, Fu TF, Hsieh CY, Chen BH, Chang HW. Concentration effects of grape seed extracts in anti-oral cancer cells involving differential apoptosis, oxidative stress, and DNA damage.BMC Complement Altern Med. 2015 Mar 29;15:94. doi: 10.1186/s12906-015-0621-8.
8. Huang HW, Chung YA, Chang HS, Tang JY, Chen IS, Chang HW. Antiproliferative Effects of Methanolic Extracts of CryptocaryaconcinnaHance Roots on Oral Cancer Ca9-22 and CAL 27 Cell Lines Involving Apoptosis, ROS Induction, and Mitochondrial Depolarization. Scientific World Journal. 2014;2014:180462. doi: 10.1155/2014/180462. Epub 2014 Oct 15. (IF=1.2/2013, 1.7/2012)
9. Chen PH, Lee KW, Hsu CC, Chen JY, Wang YH, Chen KK, Wang HM, Huang HWCC, Huang B. Expression of a splice variant of CYP26B1 in betel quid-related oral cancer. Scientific World Journal. 2014;2014:810561. doi: 10.1155/2014/810561. Epub 2014 Jul 7. (IF=1.2/2013, 1.7/2012)
10. Tseng CN, Chang YT, Chiu HT, Chou YC, Huang HW, Cheng CC, Liao MH, Chang HW. High-throughput gender identification of penguin species using melting curve analysis. AnimBiotechnol. 2014 25(2):119-27.
11. Lin IL, Chou HL, Lee JC, Chen FW, Fong Y, Chang WC, Huang HW, Wu CY, Chang WT, Wang HM, Chiu CC. The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB. Cancer Cell Int. 2014 14(1):1-7.
12. Chang JC, Kuo HC, Hsu TY, Ou CY, Liu CA, Chuang H, Liang HM, Huang HWCC, Yang KDDifferent genetic associations of the IgE production among fetus, infancy and childhood. PLOS ONE, 8:e70362 (2013) [2013 Aug 1] IF=3.2/2014
13. Tang JY, Lee JC, Chang YT, Hou MF, Huang HW, Liaw CC, Chang HW.Longnoncoding RNAs-related diseases, cancers, and drugs. ScientificWorldJournal, 2013,:943539 (2013) Jun 6
14. Tang JY, Lee JC, Hou MF, Wang CL, Chen CC, Huang HW, Chang HW.Alternative splicing for diseases, cancers, drugs, and databases.ScientificWorldJournal. 2013:703568. (2013) May 22
15. Lee JC, Hou MF, Huang HW, Chang FR, Yeh CC, Tang JY, Chang HW.Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties.Cancer Cell Int. 13(1):55. (2013) Jun 3
16. Chiu CC, Haung JW, Chang FR, Huang KJ, Huang HM, Huang HW, Chou CK, Wu YC, Chang HW.Golden berry-derived 4β-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways.PLoS One.8(5):e64739. (2013) May21
17. Chiu KH, Hsieh FM, Chen YY, Huang HW, Shiea J, Mok HK.Parvalbumin characteristics in the sonic muscle of a freshwater ornamental grunting toadfish (Allenbatrachusgrunniens).Fish PhysiolBiochem. 39(2):107-109. (2013) Apr 29
18. Yen CY, Huang CY, Hou MF, Yang YH, Chang CH, Huang HW, Chen CH, Chang HW . Evaluating the performance of fibronectin 1 (FN1), integrin α4β1 (ITGA4), syndecan-2 (SDC2), and glycoprotein CD44 as the potential biomarkers of oral squamous cell carcinoma (OSCC). Biomarkers. 18(1):63-72. (2013) Feb
19. Tseng CN, Chang HW, Stocker J, Wang HC, Lu CC, Wu CH, Yang JG, Cho CL, Huang HWc.A method to identify RNA A-to-I editing targets using I-specific cleavage and exon array analysis.Mol Cell Probes.27(1):38-45. (2013)
20. Yeh CC, Tseng CN, Yang JI, Huang HW, Fang Y, Tang JY, Chang FR, Chang HW.Antiproliferation and induction of apoptosis in Ca9-22 oral cancer cells by ethanolic extract of Gracilariatenuistipitata.Molecules. 17(9):10916-27 (2012)
21. Yeh CC, Yang JI, Lee JC, Tseng CN, Chan YC, Hseu YC, Tang JY, Chuang LY, Huang HW, Chang FR, Chang HW.Anti-proliferative effect of methanolic extract of Gracilariatenuistipitata on oral cancer cells involves apoptosis, DNA damage, and oxidative stress.BMC Complement Altern Med. 12(1):142. (2012)
22. Chang YF, Chou HJ, Yen YC, Chang HW, Hong YR, Huang HWcc, Tseng CN.Agrin induces association of Chrna1 mRNA and nicotinic acetylcholine receptor in C2C12 myotubes.FEBS Lett. 586(19):3111-6. (2012)
23. Meng FY, Tsao MZ, Huang ML, Huang HWc.Laparoscopic cholecystectomy techniques with special care treatment in acute cholecystitis patients regardless of operation timing.Hepatogastroenterology. 59(116):1006-9. (2012)
