kuang
Name: Kuang-hung Cheng (鄭光宏)
Office Address: IR4010, International Research Bldg, Biomedical Science Institute,
70 Lien-Hai Rd, Kaohsiung, Taiwan 807
E-mail: khcheng@faculty.nsysu.edu.tw
Telephone: 886-7-5252000 ext 5817
EDUCATION:
Ph.D. in Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA USA (2004)
M.S. in Molecular Biology, National Chung Hsing University, Taichung, Taiwan (1995)
B.S. in Technology for Medical Sciences, Kaohsiung Medical College, Kaohsiung, Taiwan (1992)
APPOINTMENTS:
8/2014-Present Associate Professor, Graduate Institute of Biomedical Science
National Sun Yat-Sen University
Kaohsiung, Taiwan
8/2008-7/2014 Assistant Professor, Graduate Institute of Biomedical Science
National Sun Yat-Sen University
Kaohsiung, Taiwan
1/2007-7/2008 Research fellow, Department of Pathology,
Brigham and Women’s Hospital/Harvard Medical School,
Boston, MA USA
1/2005-1/2007 Research fellow, Cancer Center, Department of Medicine,
Massachusetts General Hospital/ Harvard Medical School,
Boston, MA USA
AWARDS AND HONORS:
2008 Ruth L. Kirschstein National Research Service Award Fellowship (2nd year), USA
2007 Program of Excellence Award, the Ovarian Cancer Research Fund, Inc., USA
2007 Ruth L. Kirschstein National Research Service Award Fellowship, USA
SELECTED PUBLICATIONS:
1. C-C., Weng, H-S., Vincent, Chang, SA. Johnsen, M., Subramaniam, Winston
C.Y. Yu, C-Y., Chen, W-C., Hung, L.Z., Chen and Cheng, KH (2016, Dec). Inactivation of conditional KLF10 in the pancreas provokes rapid metastasis of pancreatic ductal adenocarcinoma in the KrasG12D p53flox/flox model. Oncogene. (Accepted). MOST 101-2628-B-110-001-MY2..
2. Liu, C-J., Kuo, F-C., Wang, C-L., Kuo, C-H., Sophie S.W. Wang, Chen, C-Y., Hunag, Y-B., Cheng, K-H., Yokoyama, K., Chen, C-L., Ku, C-Y., Wu, D-C (2016, May). Suppression of IL8-Src Signaling Axis by 17β-Estradiol Inhibits Human Mesenchymal Stem Cells-Mediated Gastric Cancer Invasion.. J. Cell. Mol. Med, 20(5):962-72..
3. Tzu-Lei Kuo, Ching-Chieh Weng, Kung-Kai Kuo, Chiao-Yun Chen, Deng- Chyang Wu, Wen-Chun Hung, Kuang- Hung Cheng (2016, Apr). APC haploinsufficiency coupled with P53 loss is sufficient to induce mucinous cystic neoplasms and invasive pancreatic carcinoma in mice. Oncogene, Apr 28;35(17):2223-34.. MOST 101-2628-B-110-001-MY2.
4. Ching-Chieh Weng*, Kung-Kai Kuo*, Huei-Ting Su, Pi-Jung Hsiao, Yu-Wen Chen, Deng-Chyang Wu, Wen-Chun Hung, Kuang- Hung Cheng (2016, Mar). Pancreatic tumor progression associated with CD133 overexpression: involvement of increased TERT expression and EGFR-dependent Akt Activation. Pancreas, 45(3):443-57. . MOST 101-2628-B-110-001-MY2.
5. Kung Kai Kuo*, Chao Jen Kuo*, Chiang Yen Chiu, Shih Shin Liang, Shu Wen Chi, Kun Bow Tsai, Chiao Yun Chen, Edward Hsi, Kuang Hung Cheng, Shyh Horng Chiou (2016, Jan). Quantitative Proteomic Analysis of Differentially Expressed Profiles Involved In the Progression of Pancreatic Ductal Adenocarcinoma. Pancreas, 45(1): 71–83... MOST 101-2628-B-110-001-MY2.
6. Kung-Kai Kuo*, Shu-Fang Jian*, Yi-Jin Li, Shih-Wei Wan, Ching-Chieh Weng, Kuan Te Fang, Deng-Chyang Wu and Kuang- Hung Cheng (2015, Jul). Epigenetic Inactivation of TGFbeta1 Target Gene HEYL, a Novel Tumor Suppressor, Involved in the P53 Induced Apoptotic Pathway in Hepatocellular Carcinoma.. Hepatology Research, Jul;45(7):782-93.. NSC 101-2628-B-110-01-MY2.
7. Liu CJ, Kuo FC, Hu HM, Chen CY, Huang YB, Cheng KH, Yokoyama KK, Wu DC, Hsieh S, Kuo CH. (2014, Jul). 17β-Estradiol inhibition of IL-6-Src and Cas and paxillin pathway suppresses human mesenchymal stem cells-mediated gastric cancer cell motility. Translation Research, 164(3):232-43..
8. Tsai JH, Kuo CH, Yang P, Cheng KH, Wang PW, Chen CC, Hung CH. (2014, Jul). Effects of Antidepressants on IP-10 Production in LPS-Activated THP-1 Human Monocytes.. Int J Mol Sci., 28;15(8):13223-35..
9. Chu TH, Chan HH, Kuo HM, Liu LF, Hu TH, Sun CK, Kung ML, Lin SW, Wang EM, Ma YL, Cheng KH, Lai KH, Wen ZH, Hsu PI, Tai MH. (2014, May). Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN. Oncotarget, 30;5(6):1475-90.
10. Shu-Fang Jian, Chang-Chun Hsiao, Shin-Yi Chen, Ching-Chieh Weng, Tzu-Lei Kuo, Deng-Chyang Wu, Wen-Chun Hung and Kuang-Hung Cheng (2014, Apr). Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1-APC Interaction in Modulating Wnt/β-Catenin Pathway of Lung Cancer Cells. Molecular Cancer Research, Mol Cancer Res. 2014 Apr;12(4):622-35.NSC 101-2628-B-110-001-MY2.
11. Yu-Wen Chen, Pi-Jung Hsiao, , Ching-Chieh Weng, Kung-Kai Kuo, Tzu-Lei Kuo, Deng-Chyang Wu, Wen-Chun Hung, Kuang-Hung Cheng (2014, Apr). SMAD4 Loss Triggers the Phenotypic Changes of Pancreatic Ductal Adenocarcinoma Cells. BMC Cancer, 2014 March 14; 14(1) 181-188. NSC 101- 2314-B-110-001-MY2.
12. Pei-Chen Wang+, Ching-Chieh Weng+, You-Syuan Hou, Shu-Fang Jian, Kuan- Te Fang , Ming-Feng Hou and Kuang-Hung Cheng (2014, Feb). Activation of VCAM-1 and Its Associated Molecule CD44 Leads to Increased Malignant Potential of Breast Cancer Cells . International Journal of Molecular Sciences, Int. J. Mol. Sci. 2014, 15(3), 3560-3579; doi:10.3390/ijms15033560. NSC 101- 2628-B-110-001-MY2.
13. Suresh Kumar Kailasa*, Kuang-Hung Cheng* and Hui-Fen Wu (2013, Dec). Semiconductor Nanomaterials-Based Fluorescence Spectroscopic and Matrix- Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometric Approaches to Proteome Analysis. Materials. (SCI).
14. Hong KJ, Wu DC, Cheng KH, Chen LT, Hung WC. (2013, Jul). RECK inhibits stemness gene expression and tumorigenicity of gastric cancer cells by suppressing ADAM-mediated Notch1 activation.. J Cell Physiol. , Jul 23. doi:10.1002/jcp.24434..
15. Su HT, Weng CC, Hsiao PJ, Chen LH, Kuo TL, Chen YW, Kuo KK, Cheng KH (2013, Jul). Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer.. Molecular Cancer Research, Jul;11(7):768-79.. NSC 98-2320-B-110-003-MY3.
16. Chiou YS, Sang S, Cheng KH, Ho CT, Wang YJ, Pan MH. (2013, Jun). Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors.. Carcinogenesis, 34(6):1315-22..
17. Tsai JH, Yang P, Lin HH, Cheng KH, Yang YH, Wu MT, Chen CC. (2013, Feb). Association between GABA(A) receptor subunit gene cluster and zolpidem- induced complex sleep behaviors in Han Chinese.. Sleep, 36(2):197-202. .
18. McAuliffe SM, Morgan SL, Wyant GA, Tran LT, Muto KW, Chen YS, Chin KT, Partridge JC, Poole BB, Cheng KH, Daggett J Jr, Cullen K, Kantoff E, Hasselbatt K, Berkowitz J, Muto MG, Berkowitz RS, Aster JC, Matulonis UA, Dinulescu DM. (2012, Oct). Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy.. Proc Natl Acad Sci U S A. , 109(43):E2939-48. .
19. Chiang-Yen Chiu, Kung-Kai Kuo, Tzu-Lei Kuo, King-The Lee, Kuang-Hung Cheng (2012, Mar). The activation of MEK/ERK signaling pathway by bone morphogenetic protein 4 to increase hepatocellular carcinoma cell proliferation and migration. . Molecular Cancer Research, 10(3):415-27. (SCI). NSC 98-2314-B-037-027-MY3.
20. Kuang-Hung Cheng, Tzu-Lei Kuo, Kung-Kai Kuo, Chang-Chun Hsiao (2011, Oct). Human Adipose-Derived Stem Cells: Isolation; Characterization And Current Application In Regeneration Medicine . Genomic Medicine, Biomarkers, and Health Sciences . (SCI). NSC 98-2320-B-110-003-MY3.
21. P. Papageorgis, K.H. Cheng, A. W. Lambert1, S.Ozturk1,A. Hamid, J.R. Zhou and S. Thiagalingam*. (2011, Jan). Smad4 inactivation promotes malignancy and drug resistance of colorectal cancer.. Cancer Research, doi: 10.1158/0008- 5472.CAN-09-3269. (SCI).
Book Chapter.
1. H-W. Huang, H-W. Chang, T-L. Kuo, K-H. Cheng. BMP signaling in primordial germ cell development and maturation. (2011) . Book Title: Bone Morphogenetic Proteins: New Research ; Book chapter, Nova Science Publishers. Nov, 2011. NSC 98-2329-B-110-003-MY3.
