Yow-Ling Shiue / Professor
專長領域：基因體學、生物資訊學、胚幹細胞與疫苗、藥物機轉、基因調控、訊息傳遞
聯絡電話：07-5252000分機:5818
E-mail：shirley@imst.nsysu.edu.tw
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| 1981-1985 | 國立台灣大學 B.S. | ||
| 1994-1996 | University of California, Davis M.S. | ||
| 1996-1999 | University of California, Davis Ph.D. | ||
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| 1986 - 1993 | 台灣省畜產試驗所育種系委任（五職等）助理 | ||
| 1994 - 1999 | Vet. Genet. Lab. University of California,Davis Post-graduated researcher | ||
| 1999 - 2001 | 國立成功大學生物科技研究所博士後研究員 | ||
| 2001 - 2007 | 國立中山大學生物醫學研究所助理教授 | ||
| 2007 -2012 | 國立中山大學生物醫學研究所副教授 | ||
| 2012- | 國立中山大學生物醫學研究所教授 | ||
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| 1.肝癌與膀胱癌轉譯醫學研究 | |||
| 2.脊椎動物性別決定 | |||
| 3.胚幹細胞與疫苗 | |||
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| 1. 1985--通過國家高等考試 | |||
| 2. 1991、1992、1993--NSC Excellent Year-term Paper(國科會乙等獎) | |||
| 3. 1995--Fellowship, Genetics Graduate Group (GGG), University of California, Davis, USA | |||
| 4. 1994、1996-1999--Fellowship, Vet. School, University of California, Davis, USA | |||
| 5. 2006理學院傑出教學教師 | |||
| 6. 2009 The Marquis Who's Who in the World | |||
| 7. 2008理學院傑出教學教師 | |||
| 8. 2011-2012 Editorial Advisory Board 'Animal Reproduction Science | |||
| 9. 2011-2012 Editorial Advisory Board 'Genomic Medicine, Biomarkers, and Health Science | |||
| 10.2010-2012理學院研究績優 | |||
| 11.與畜產試驗所合作之「豬胚幹細胞應用於人類疾病模式之應用與治療」榮獲第十一屆國家新創獎 | |||
| 12.2016年理學院研究績優 | |||
| 13.2014-2016「現今科技與社會」、「基礎生物學」全校優良課程 | |||
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| 1 | Li CF, Wu WR, Chan TC, Wang YH, Chen LR, Wu WJ, Yeh BW, Liang SS, Shiue YL*. Transmembrane and coiled-coil domain 1 impairs the AKT signaling pathway in urinary bladder urothelial carcinoma: a characterization of a tumor suppressor. Clin Cancer Res. 2017 Sep 29. pii: clincanres.0002.2017. doi:10.1158/1078-0432.CCR-17-0002. [Epub ahead of print] PubMed PMID: 28972042. | ||
| 2 | Tseng HW, Liou HH, Tsai KW, Ger LP, Shiue YL*. Clinicopathological study of lip cancer: a retrospective hospital-based study in Taiwan. APMIS. 2017 Sep 15. doi: 10.1111/apm.12751. [Epub ahead of print] PubMed PMID: 28913905. | ||
| 3 | Lim SW, Eric Nyam TT, Ho CH, Shiue YL, Wang JJ, Chio CC, Kuo JR. Increased Risk of Anxiety or Depression After Traumatic Spinal Cord Injury in Patients with Preexisting Hyperlipidemia: A Population-Based Study. World Neurosurg. 2017 Oct;106:402-408. | ||
| 4 | Wu TC, Chen TY, Shiue YL, Chen JH, Hsieh TJ, Ko CC, Lin CP. Added value of delayed computed tomography angiography in primary intracranial hemorrhage and hematoma size for predicting spot sign. Acta Radiol. 2017 Jan 1:284185117718401. doi: 10.1177/0284185117718401. | ||
| 5 | Yu SC, Kuo JR, Shiue YL, Yu ZX, Ho CH, Wu CC, Wang JJ, Chu CC, Lim SW. One-Year Mortality of Patients with Chronic Kidney Disease After Spinal Cord Injury: A 14-Year Population-Based Study. World Neurosurg. 2017 Sep;105:462-469. | ||
| 6 | Lee HY, Yeh BW, Chan TC, Yang KF, Li WM, Huang CN, Ke HL, Li CC, Yeh HC, Liang PI, Shiue YL, Wu WJ, Li CF. Sulfatase-1 overexpression indicates poor prognosis in urothelial carcinoma of the urinary bladder and upper tract. Oncotarget. 2017 Jul 18;8(29):47216-47229. doi: 10.18632/oncotarget.17590. | ||
| 7 | Lim SW, Shiue YL, Ho CH, Yu SC, Kao PH, Wang JJ, Kuo JR. Anxiety and Depression in Patients with Traumatic Spinal Cord Injury: A Nationwide Population-Based Cohort Study. PLoS One. 2017 Jan 12;12(1):e0169623. doi:10.1371/journal.pone.0169623. eCollection 2017. | ||
| 8 | Lin YR, Huang MF, Wu YY, Liu MC, Huang JH, Chen Z, Shiue YL, Wu CE, Liang SS. Reductive amination derivatization for the quantification of garlic components by isotope dilution analysis. Food Chem. 2017 Sep 1;230:1-5. doi:10.1016/j.foodchem.2017.02.119. Epub 2017 Feb 27. PubMed PMID: 28407889 | ||
| 9 | Lim SW, Sung KC, Shiue YL, Wang CC, Chio CC, Kuo JR. Hyperbaric Oxygen Effects on Depression-Like Behavior and Neuroinflammation in Traumatic Brain Injury Rats. World Neurosurg. 2017 Apr;100:128-137. doi:10.1016/j.wneu.2016.12.118. Epub 2017 Jan 6. PubMed PMID: 28065873. | ||
| 10 | Yang CM, Wang TH, Chen HC, Li SC, Lee MC, Liou HH, Liu PF, Tseng YK, Shiue YL, Ger LP, Tsai KW. Aberrant DNA hypermethylation-silenced SOX21-AS1 gene expression and its clinical importance in oral cancer. Clin Epigenetics. 2016 Nov 26;8:129. eCollection 2016. | ||
| 11 | Wei RJ, Lin SS, Wu WR, Chen LR, Li CF, Chen HD, Chou CT, Chen YC, Liang SS, Chien ST, Shiue YL*. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016 Nov 15;311:88-98. | ||
| 12 | Hsieh PF, Liu SF, Hung TJ, Hung CY, Liu GZ, Chuang LY, Chen MF, Wang JL, Shi MD, Hsu CH, Shiue YL*, Yang YL*. Elucidation of the therapeutic role of mitochondrial biogenesis transducers NRF-1 in the regulation of renal fibrosis. Exp Cell Res. 2016 Nov 15;349(1):23-31. | ||
| 13 | Liu W, Shiue YL, Lin YR, Lin HY, Liang SS. A Derivative Method with Free Radical Oxidation to Predict Resveratrol Metabolites by Tandem Mass Spectrometry. Curr Anal Chem. 2015 Oct;11(4):300-306. | ||
| 14 | Hsieh PF, Liu SF, Hung TJ, Hung CY, Liu GZ, Chuang LY, Chen MF, Wang JL, Shi MD, Hsu CH, Shiue YL*, Yang YL*. Treatment with cytokine thymic stromal lymphopoietin short hairpin RNA substantially reduces TGF-β1-induced interstitial cellular fibrosis. Exp Cell Res. 2016 Sep 10;347(1):153-60. | ||
| 15 | Lim SW, Shiue YL, Liao JC, Wee HY, Wang CC, Chio CC, Chang CH, Hu CY, Kuo JR. Simvastatin Therapy in the Acute Stage of Traumatic Brain Injury Attenuates Brain Trauma-Induced Depression-Like Behavior in Rats by Reducing Neuroinflammation in the Hippocampus. Neurocrit Care. 2017 Feb;26(1):122-132. | ||
| 16 | Wu YT, Yen SL, Li CF, Chan TC, Chen TJ, Lee SW, He HL, Chang IW, Hsing CH, Shiue YL*. Overexpression of Transient Receptor Protein Cation Channel Subfamily A Member 1, Confers an Independent Prognostic Indicator in Nasopharyngeal Carcinoma. J Cancer. 2016 Jun 8;7(10):1181-8. doi: 10.7150/jca.15326. eCollection | ||
| 17 | Tseng HW, Shiue YL, Tsai KW, Huang WC, Tang PL, Lam HC. Risk of skin cancer in patients with diabetes mellitus: A nationwide retrospective cohort study in Taiwan. Medicine (Baltimore). 2016 Jun;95(26):e4070. | ||
| 18 | Shiue YL, Yang JR, Liao YJ, Kuo TY, Liao CH, Kang CH, Tai C, Anderson GB, Chen LR. Derivation of porcine pluripotent stem cells for biomedical research. Theriogenology. 2016 Jul 1;86(1):176-81. doi:10.1016/j.theriogenology.2016.04.030. Epub 2016 Apr 21. Review. PubMed PMID:27158128. | ||
| 19 | He HL, Lee YE, Liang PI, Lee SW, Chen TJ, Chan TC, Hsing CH, Chang IW, Shiue YL, Li CF. Overexpression of JAK2: a predictor of unfavorable prognosis for nasopharyngeal carcinoma. Future Oncol. 2016 Aug;12(16):1887-96. | ||
| 20 | He HL, Lee YE, Shiue YL, Lee SW, Chen TJ, Li CF. Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma. Medicine (Baltimore). 2015 Dec;94(49):e2271. doi: 10.1097/MD.0000000000002271. | ||
| 21 | Yang CJ, Liu YP, Dai HY, Shiue YL, Tsai CJ, Huang MS, Yeh YT. Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer. Oncotarget. 2015 Oct 6;6(30):30263-76. doi: 10.18632/oncotarget.4749. | ||
| 22 | Wang YH, Wu WJ, Wang WJ, Huang HY, Li WM, Yeh BW, Wu TF, Shiue YL, Sheu JJ, Wang JM, Li CF. CEBPD amplification and overexpression in urothelial carcinoma: a driver of tumor metastasis indicating adverse prognosis. Oncotarget. 2015 Oct 13;6(31):31069-84. | ||
| 23 | Li CF, Wu WJ, Wu WR, Liao YJ, Chen LR, Huang CN, Li CC, Li WM, Huang HY, Chen YL, Liang SS, Chow NH, Shiue YL*. The cAMP responsive element binding protein 1 transactivates epithelial membrane protein 2, a potential tumor suppressor in the urinary bladder urothelial carcinoma. Oncotarget. 2015 Apr 20;6(11):9220-39. | ||
| 24 | Lee YE, He HL, Shiue YL, Lee SW, Lin LC, Wu TF, Chang IW, Lee HH, Li CF. The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy. Tumour Biol. 2015 Sep;36(10):7675-83. | ||
| 25 | He HL, Lee YE, Chen HP, Hsing CH, Chang IW, Shiue YL, Lee SW, Hsu CT, Lin LC, Wu TF, Li CF. Overexpression of DNAJC12 predicts poor response to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer. Exp Mol Pathol. 2015 Jun;98(3):338-45. | ||
| 26 | Peng YT, Wu WR, Chen LR, Kuo KK, Tsai CH, Huang YT, Lan YH, Chang FR, Wu YC, Shiue YL*. Upregulation of cyclin-dependent kinase inhibitors CDKN1B and CDKN1C in hepatocellular carcinoma-derived cells via goniothalamin-mediated protein stabilization and epigenetic modifications. Toxicol Rep. 2015 Jan | ||
| 27 | He HL, Lee YE, Shiue YL, Lee SW, Lin LC, Chen TJ, Wu TF, Li CF. PLA2G2A overexpression is associated with poor therapeutic response and inferior outcome in rectal cancer patients receiving neoadjuvant concurrent chemoradiotherapy. Histopathology. 2015 Jun;66(7):991-1002. | ||
| 28 | He HL, Lee YE, Shiue YL, Lee SW, Lin LC, Chen TJ, Wu TF, Hsing CH, Huang HY, Wang JY, Li CF. Overexpression of REG4 confers an independent negative prognosticator in rectal cancers receiving concurrent chemoradiotherapy. J Surg Oncol. 2014 Dec;110(8):1002-10. | ||
| 29 | Li CF, Huang HY, Wu WR, Liang SS, Chen YL, Chen LR, Peng YT, Lee HC, Shiue YL*. Clinical aggressiveness of myxofibrosarcomas associates with down-regulation of p12CDK2AP1: prognostic implication of a putative tumor suppressor that induces cell cycle arrest and apoptosis via mitochondrial pathway. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S711-20. | ||
| 30 | Yang SF, Chang CW, Wei RJ, Shiue YL, Wang SN, Yeh YT. Involvement of DNA damage response pathways in hepatocellular carcinoma. Biomed Res Int. 2014;2014:153867. | ||
| 31 | Wang WC, Liu SF, Chang WT, Shiue YL, Hsieh PF, Hung TJ, Hung CY, Hung YJ, Chen MF, Yang YL. The effects of diosgenin in the regulation of renal proximal tubular fibrosis. Exp Cell Res. 2014 May 1;323(2):255-62. | ||
| 32 | Hsu HP, Li CF, Lee SW, Wu WR, Chen TJ, Chang KY, Liang SS, Tsai CJ, Shiue YL*. Overexpression of stathmin 1 confers an independent prognostic indicator in nasopharyngeal carcinoma. Tumour Biol. 2014 Mar;35(3):2619-29. | ||
| 33 | Liang SS, Shiue YL, Kuo CJ, Guo SE, Liao WT, Tsai EM. Online monitoring oxidative products and metabolites of nicotine by free radicals generation with Fenton reaction in tandem mass spectrometry. ScientificWorldJournal. 2013 Jul 25;2013:189162. | ||
| 34 | Lee SW, Lin CY, Tian YF, Sun DP, Lin LC, Chen LT, Hsing CH, Huang CT, Hsu HP, Huang HY, Wu LC, Li CF, Shiue YL*. Overexpression of CDC28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma. APMIS. 2014 Mar;122(3):206-14. | ||
| 35 | Wang YW, Li WM, Wu WJ, Chai CY, Chang TY, Sun Y, Cheng CJ, Shiue YL, Su SJ, Cheng HL, Liu HS, Chow NH. Epithelial membrane protein 2 is a prognostic indictor for patients with urothelial carcinoma of the upper urinary tract. Am J Pathol. 2013 Sep;183(3):709-19. | ||
| 36 | Lee SW, Chen TJ, Lin LC, Li CF, Chen LT, Hsing CH, Hsu HP, Tsai CJ, Huang HY, Shiue YL*. Overexpression of thymidylate synthetase confers an independent prognostic indicator in nasopharyngeal carcinoma. Exp Mol Pathol. 2013 Aug;95(1):83-90. | ||
| 37 | Sun DP, Lin CY, Tian YF, Chen LT, Lin LC, Lee SW, Hsing CH, Lee HH, Shiue YL, Huang HY, Li CF, Liang PI. Clinicopathological significance of HuR expression in gallbladder carcinoma: with special emphasis on the implications of its nuclear and cytoplasmic expression. Tumour Biol. 2013 Oct;34(5):3059-69. | ||
| 38 | Huang HY, Wu WR, Wang YH, Wang JW, Fang FM, Tsai JW, Li SH, Hung HC, Yu SC, Lan J, Shiue YL, Hsing CH, Chen LT, Li CF. ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance. Clin Cancer Res. 2013 Jun 1;19(11):2861-72. | ||
| 39 | Liang PI, Wang YH, Wu TF, Wu WR, Liao AC, Shen KH, Hsing CH, Shiue YL, Huang HY, Hsu HP, Chen LT, Lin CY, Tai C, Wu JY, Li CF. IGFBP-5 overexpression as a poor prognostic factor in patients with urothelial carcinomas of upper urinary tracts and urinary bladder. J Clin Pathol. 2013 Jul;66(7):573-82. | ||
| 40 | Tian YF, Chen TJ, Lin CY, Chen LT, Lin LC, Hsing CH, Lee SW, Sheu MJ, Lee HH, Shiue YL, Huang HY, Pan HY, Li CF, Chen SH. SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential. Tumour Biol. 2013 Apr;34(2):1107-17. | ||
| 41 | Yang JR, Liao CH, Pang CY, Huang LL, Chen YL, Shiue YL, Chen LR. Transplantation of porcine embryonic stem cells and their derived neuronal progenitors in a spinal cord injury rat model. Cytotherapy. 2013 Feb;15(2):201-8. | ||
| 42 | Kao YC, Lee SW, Lin LC, Chen LT, Hsing CH, Hsu HP, Huang HY, Shiue YL, Chen TJ, Li CF. Fatty acid synthase overexpression confers an independent prognosticator and associates with radiation resistance in nasopharyngeal carcinoma. Tumour Biol. 2013 Apr;34(2):759-68. | ||
| 43 | Yip HK, Sun CK, Tsai TH, Sheu JJ, Kao YH, Lin YC, Shiue YL, Chen YL, Chai HT, Chua S, Ko SF, Leu S. Tissue plasminogen activator enhances mobilization of endothelial progenitor cells and angiogenesis in murine limb ischemia. Int J Cardiol. 2013 Sep 20;168(1):226-36. | ||
| 44 | Chen YL, Uen YH, Li CF, Horng KC, Chen LR, Wu WR, Tseng HY, Huang HY, Wu LC, Shiue YL*. The E2F transcription factor 1 transactives stathmin 1 in hepatocellular carcinoma. Ann Surg Oncol. 2013 Nov;20(12):4041-54. | ||
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